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Biasing neural activity
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Biasing neural activity
SubTitle
entrainment of cortical neurons by applied electric fields
Identifier
ETD_2775
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000056111
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Integrative Neuroscience
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Neural circuitry
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Electrophysiology
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Magnetic brain stimulation
Subject
(ID = SBJ-5);
(authority = ETD-LCSH)
Topic
Electric fields
Abstract
(type = abstract)
Low intensity electric fields have been suggested to affect ongoing neuronal activity in both in vitro studies and in human studies. However, the physiological mechanism of how weak electrical fields affect and interact with intact brain activity is not well understood. I performed in vivo extracellular and intracellular recordings from the neocortex of anesthetized rats and extracellular recordings in behaving rats. Electric fields were generated by sinusoid patterns at slow frequency (0.7, 0.8, 1.25 or 1.7 Hz) via electrodes placed on the surface of the skull or the dura. Transcranial electric stimulation (TES) reliably entrained neurons directly in widespread cortical areas, including the hippocampus. The percentage of TES phase-locked neurons increased with stimulus intensity and depended on the behavioral state of the animal. TES-induced voltage gradient, as low as 1 mV/mm at the recording site, was sufficient to phase-bias neuronal spiking. TES-induced effects were rapid to evolve and disappeared quickly after TES-offset. Intracellular recordings showed that both subthreshold and spiking activity of neurons were under the combined influence of TES forced fields and network activity. Our findings suggest that TES in chronic preparations may be used for experimental and therapeutic control of brain activity.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
xvi, 137 p. : ill.
InternetMediaType
application/pdf
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text/xml
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Şimal Özen
Name
(ID = NAME-1);
(type = personal)
NamePart
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Özen
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Şimal
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(type = date)
1981-
Role
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author
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Simal Ozen
Name
(ID = NAME-2);
(type = personal)
NamePart
(type = family)
Pare
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(type = given)
Denis
Role
RoleTerm
(authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Denis Pare
Name
(ID = NAME-3);
(type = personal)
NamePart
(type = family)
Buzsaki
NamePart
(type = given)
Gyorgy
Role
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(authority = RULIB)
co-chair
Affiliation
Advisory Committee
DisplayForm
Gyorgy Buzsaki
Name
(ID = NAME-4);
(type = personal)
NamePart
(type = family)
Krekelberg
NamePart
(type = given)
Bart
Role
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(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Bart Krekelberg
Name
(ID = NAME-5);
(type = personal)
NamePart
(type = family)
Zaborszky
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(type = given)
Laszlo
Role
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(authority = RULIB)
internal member
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Advisory Committee
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Laszlo Zaborszky
Name
(ID = NAME-6);
(type = personal)
NamePart
(type = family)
McCormick
NamePart
(type = given)
David
Role
RoleTerm
(authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
David McCormick
Name
(ID = NAME-1);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010-10
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T32B8XT4
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Ozen
GivenName
Simal
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-07-05 03:24:37
AssociatedEntity
(ID = AE-1);
(AUTHORITY = rulib)
Role
Copyright holder
Name
Simal Ozen
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
(ID = AO-1);
(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
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application/x-tar
FileSize
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3317760
Checksum
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