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Transdermal and transbuccal drug delivery

Descriptive

TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Transdermal and transbuccal drug delivery
SubTitle
enhancement using iontophoresis and chemical enhancers
Identifier
ETD_2806
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056369
Language
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Pharmaceutical Science
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Drug delivery systems
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Transdermal medication
Subject (ID = SBJ-4); (authority = ETD-LCSH)
Topic
Iontophoresis
Abstract (type = abstract)
Transdermal and transbuccal routes offer attractive alternatives for systemic delivery of drugs due to their distinct advantages: non-invasive, avoidance of first-pass effect, improved bioavailability and reduction of systemic side effects. However, only a few drugs have been successfully delivered into blood stream to reach therapeutic levels without causing notable skin irritation or damage. Transbuccal drug delivery systems are still at research stage. The major barriers to transdermal and transbuccal drug delivery are stratum corneum of skin and epithelium of buccal tissue. The objective of this work was to overcome these barriers to significantly enhance transdermal and transbuccal delivery of hydrophilic drugs without causing major damage to skin and buccal tissue. In this work, iontophoresis, chemical enhancers and their combination were investigated for their enhancement effects on transdermal and transbuccal delivery of hydrophilic drugs with different indications: lidocaine HCl (LHCl) for pain management, nicotine hydrogen tartrate (NHT) for smoking cessation, diltiazem HCl (DHCl) for anti-hypertension and ondansetron HCl (ODAN HCl) for anti-vomiting. Low toxic chemical enhancers used were dodecyl 2-(N, N-dimethyl amino) propionate (DDAIP), its HCl salt dodecyl-2-(N, N-dimethylamino) propionate hydrochloride (DDAIP HCl), N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane (Br-iminosulfurane). Their enhancement effects were evaluated using in vitro Franz cell diffusion model via porcine skin and buccal tissue. The results demonstrated that iontophoresis alone significantly enhanced transdermal and transbuccal delivery of LHCl, NHT, DHCl and ODAN HCl. DDAIP HCl alone significantly enhanced transbuccal delivery of these four drugs. DDAIP and Br-iminosulfurane significantly enhanced transdermal delivery of LHCl and ODAN HCl. Synergistic enhancement effects were observed on transdermal delivery of LHCl and NHT, ODAN HCl when using DDAIP or Br-iminosulfurane in combination with iontophoresis. A light microscopy, DSC and SEM studies showed that treatment with chemical enhancers and iontophoresis did not cause major morphological changes in the skin and buccal tissue. EpiOralâ„¢ MTS cytotoxicity study demonstrated that DDAIP HCl at less than 5% (w/v) in water did not have significant detrimental effects on buccal tissue. In conclusions, iontophoresis and chemical enhancer and their combined treatment are feasible approaches to enhance transdermal and transbuccal delivery of LHCl, NHT, DHCl and ODAN HCl.
PhysicalDescription
Form (authority = gmd)
electronic resource
Extent
xxi, 233 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Lonsheng Hu
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Hu
NamePart (type = given)
Longsheng
Role
RoleTerm (authority = RULIB)
author
DisplayForm
Longsheng Hu
Name (ID = NAME-2); (type = personal)
NamePart (type = family)
Michniak-Kohn
NamePart (type = given)
Bozena
Role
RoleTerm (authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Bozena Michniak-Kohn
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Minko
NamePart (type = given)
Tamara
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Tamara Minko
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
You
NamePart (type = given)
Guofeng
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Guofeng You
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Dayan
NamePart (type = given)
Nava
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Nava Dayan
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated (qualifier = exact)
2010
DateOther (qualifier = exact); (type = degree)
2010
Place
PlaceTerm (type = code)
xx
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T39S1QS6
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = PRH-1); (type = personal)
Name
FamilyName
Hu
GivenName
Longsheng
Role
Copyright Holder
RightsEvent (ID = RE-1); (AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-08-10 20:50:16
AssociatedEntity (ID = AE-1); (AUTHORITY = rulib)
Role
Copyright holder
Name
Longsheng Hu
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject (ID = AO-1); (AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

ContentModel
ETD
MimeType (TYPE = file)
application/pdf
MimeType (TYPE = container)
application/x-tar
FileSize (UNIT = bytes)
4065280
Checksum (METHOD = SHA1)
4ee3d9764836342680c1348f281670c424f1cd63
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