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Polymer and tissue separation and micro/nano-fabrication via ultra-short pulsed laser plasma-mediated ablation

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TypeOfResource
Text
TitleInfo
Title
Polymer and tissue separation and micro/nano-fabrication via ultra-short pulsed laser plasma-mediated ablation
Identifier
ETD_2905
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056371
Language
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (authority = RUETD)
Topic
Mechanical and Aerospace Engineering
Subject (authority = ETD-LCSH)
Topic
Ablative materials
Subject (authority = ETD-LCSH)
Topic
Microfabrication
Subject (authority = ETD-LCSH)
Topic
Laser-induced breakdown spectroscopy
Abstract (type = abstract)
Micro/nano-fabrication of polymers and micro-processing of real human tissues via plasma-mediated ablation were investigated using an ultra-short pulsed (USP) laser of 900 fs pulse duration and 1552 nm center wavelength. For the PDMS polymer micro-fabrication, the ablation threshold for the single spot and the single line scanning ablation features were studied at first. The single pulse ablation threshold is determined to be 4.62 J/cm2 and the incubation factor for the multi-pulse ablation is found to be 0.52. The influences of pulse overlap rate and irradiation pulse energy on the ablation line width, internal ablation interface depth, and ablation surface quality were scrutinized. Then the thin layer PDMS separation was completed with thickness controllable via adjusting the laser focus spot position. For the three tests with a target thickness of 20 μm, the averaged thickness of the separated thin layers is 20.6±1.7 μm. And a multi-width micro-channel interconnected network was fabricated and the size of the channels varies from 50 to 400 μm. For the real tissue ablation, the fundamental ablation features were investigated. It is found that the threshold of the single pulse ablation for the freeze-dried dermis (8.32±0.37 J/cm2) is slightly smaller than that of the wet dermis (9.65±1.21 J/cm2) due to the light absorption of water in wet tissues. Histological examinations were performed to evaluate the thermal damage and to find appropriate laser parameters for tissue micro-processing with minimal thermal damage. An analytical solution based on the heat conduction equation was derived to analyze the temperature distributions and to obtain the heat affected zones in materials ablated by USP laser line scanning. The analytical results were compared with the experimental measurements and a good agreement was found. Both results show that the thermal damage can be confined in a small zone about 10 µm with proper pulse energy and overlap rate. Pulse energy and pulse overlap rate were the key parameters for the generation and severity of thermal damage. In vitro wet tissue separation into layers by the USP laser ablation was demonstrated with thickness ranging from 200 to 600 μm. The unevenness of the separated layers is under 10%. Freeze-dried tissue stripping was also demonstrated with the stripped thickness in the range of 20 - 40 μm. No sign of visible thermal damage was found for both types of tissues. This study has provided an effective method that can precisely and non-intrusively process polymers and tissues with minimized thermal damage.
PhysicalDescription
Form (authority = gmd)
electronic resource
Extent
xiv, 197 p. : ill.
InternetMediaType
application/pdf
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text/xml
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Huan Huang
Name (type = personal)
NamePart (type = family)
Huang
NamePart (type = given)
Huan
NamePart (type = date)
1981-
Role
RoleTerm (authority = RULIB)
author
DisplayForm
Huan Huang
Name (type = personal)
NamePart (type = family)
Guo
NamePart (type = given)
Zhixiong
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chair
Affiliation
Advisory Committee
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Zhixiong Guo
Name (type = personal)
NamePart (type = family)
Shan
NamePart (type = given)
Jerry
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Jerry Shan
Name (type = personal)
NamePart (type = family)
Bagchi
NamePart (type = given)
Prosenjit
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Prosenjit Bagchi
Name (type = personal)
NamePart (type = family)
Yong
NamePart (type = given)
Yook-Kong
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Yook-Kong Yong
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated
2010
DateOther (qualifier = exact); (type = degree)
2010-10
Place
PlaceTerm (type = code)
xx
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3K93783
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = PRH-1); (type = personal)
Name
FamilyName
Huang
GivenName
Huan
Role
Copyright Holder
RightsEvent (ID = RE-1); (AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-09-26 02:15:27
AssociatedEntity (ID = AE-1); (AUTHORITY = rulib)
Role
Copyright holder
Name
Huan Huang
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject (ID = AO-1); (AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

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application/pdf
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application/x-tar
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