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Investigation of novel penetration modifiers as enhancers and retardants and human pharmacokinetics and pharmacodynamics of orally administered Quercetin
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Investigation of novel penetration modifiers as enhancers and retardants and human pharmacokinetics and pharmacodynamics of orally administered Quercetin
TitleInfo
(ID = T-2);
(type = alternative)
Title
Human pharmacokinetics and pharmacodynamics of orally administered Quercetin
Identifier
ETD_2815
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056451
Language
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eng
Genre
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theses
Subject
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(authority = RUETD)
Topic
Pharmaceutical Science
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Pharmacokinetics
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Skin--Effect of drugs on
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Quercetin
Abstract
(type = abstract)
The delivery of the actives through the outermost layer of the skin, the stratum corneum has posed a challenge for scientists for a very long time. There are compound called “enhancers” that have been developed to enhance drug delivery across skin and at the same time there are compounds referred to as “retardants” that prevent or retard the delivery of actives across the skin. Since both enhancers and retardants are believed to act by modifying the properties of the SC barrier, they are collectively referred to as “penetration modifiers”. The first part of the study aimed at investigating five penetration modifiers that are analogues of laurocapram and iminosulfurane. These penetration modifiers were evaluated initially for their enhancement/retardation potential by computer modeling and investigated for their physical attributes (solubility, lipophilicity, etc.) and formulation effects. The effect of permeation modifier formulations (prepared in commonly used pharmaceutical vehicles) on permeation of model permeants were evaluated and mechanistic studies were performed using thermal, spectral and microscopic analyses. The penetration modifiers were also assessed for their in vitro permeation and cytotoxicity using MTS assay. These investigations should lead to a better understanding of the properties, effects and mechanisms of action of penetration modifiers. The second part of the dissertation covers human pharmacokinetics and pharmacodynamics of quercetin. Quercetin is a naturally occurring flavonoid with antioxidant and anti-inflammatory potential. In order to assess some of benefits of quercetin, this investigation examined the pharmacokinetics and pharmacodynamics of orally administered formulations to human healthy volunteers. Initially, we developed and validated a quercetin assay in human plasma and urine followed by selection of suitable oral carrier for pharmacodynamics study based on pharmacokinetic profiles of three nutritional carrier systems. This was followed by determination of the effects of quercetin supplementation on improving maximal oxygen uptake, enhancing exercise performance during heat stress and relief of muscle soreness. We expect to make conclusions regarding effects of quercetin in overall improvement in work performance of human subjects that would in turn enable the U.S. Department of Defense to consider inclusion of quercetin in daily rations for soldiers to further improve their performance.
PhysicalDescription
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electronic resource
Extent
xxvii, 273 p. : ill.
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application/pdf
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text/xml
Note
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Ph.D.
Note
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Includes bibliographical references
Note
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Includes vita
Note
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by Diksha Kaushik
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Kaushik
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Diksha
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1978-
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author
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Diksha Kaushik
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Michniak-Kohn
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Bozena B
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chair
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Advisory Committee
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Bozena B Michniak-Kohn
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Minko
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Tamara
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internal member
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Advisory Committee
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Tamara Minko
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You
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(type = given)
Guofeng
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internal member
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Guofeng You
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Dayan
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Nava
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outside member
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Advisory Committee
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Nava Dayan
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2010
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2010-10
Place
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xx
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T3NC60ZM
Genre
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ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
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Name
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Kaushik
GivenName
Diksha
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Copyright Holder
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Permission or license
DateTime
2010-08-17 11:58:49
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Diksha Kaushik
Affiliation
Rutgers University. Graduate School - New Brunswick
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Embargo
DateTime
2010-10-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2011.
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