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A neuromuscular junction-based neural interface
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
A neuromuscular junction-based neural interface
SubTitle
the myotube-integrated microelectrode array
Identifier
ETD_2773
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056480
Language
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(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Biomedical Engineering
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Microelectrodes
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Myoelectric prosthesis
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Neural transmission
Abstract
(type = abstract)
Neural interface designs are diverse, including multiple cortical, deep brain, spinal, non-invasive, and PNS-based approaches to stimulation and recording. There are an estimated 1.7 million Americans living with limb loss, and many more suffering from PNS
injury without expected motor recovery, who may benefit from a neural interface that can help place a prosthetic actuator directly under neural control. Technologies exist capable of recording neural activity from both the PNS and CNS, but they face problems acquiring large enough numbers of independent and appropriately tuned neural signals to provide reliable dexterous control. This dissertation introduces a new neural interface design that uses myotubes cultured on a topographically modified MEA as a means of
extracting large numbers of independent neural signals pertaining to motor control from the PNS. To provide proof of principal for the basic science concepts underpinning this design, the following three aims are pursued and results are discussed: Aim 1 – To develop a bio-interface capable of modulating myotube behavior and guiding myotube formation and contractility to specific locations. Aim 2 – To integrate the bio-interface from Aim 1with a substrate-embedded MEA for
the purpose of recording myotube activity selectively from independent myotubes within a culture. Aim 3 – To integrate the interface designed in Aims 1 and 2 with neuronal culture, as the first step towards developing a structured co-culture system.
injury without expected motor recovery, who may benefit from a neural interface that can help place a prosthetic actuator directly under neural control. Technologies exist capable of recording neural activity from both the PNS and CNS, but they face problems acquiring large enough numbers of independent and appropriately tuned neural signals to provide reliable dexterous control. This dissertation introduces a new neural interface design that uses myotubes cultured on a topographically modified MEA as a means of
extracting large numbers of independent neural signals pertaining to motor control from the PNS. To provide proof of principal for the basic science concepts underpinning this design, the following three aims are pursued and results are discussed: Aim 1 – To develop a bio-interface capable of modulating myotube behavior and guiding myotube formation and contractility to specific locations. Aim 2 – To integrate the bio-interface from Aim 1with a substrate-embedded MEA for
the purpose of recording myotube activity selectively from independent myotubes within a culture. Aim 3 – To integrate the interface designed in Aims 1 and 2 with neuronal culture, as the first step towards developing a structured co-culture system.
PhysicalDescription
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electronic resource
Extent
xv, 226 p. : ill.
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application/pdf
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text/xml
Note
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Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Christopher Gresham Langhammer
Name
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(type = personal)
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Langhammer
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Christopher Gresham
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1980-
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author
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Christopher Langhammer
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Firestein
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Bonnie
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chair
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Advisory Committee
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Bonnie Firestein
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Zahn
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Jeffrey
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internal member
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Advisory Committee
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Jeffrey Zahn
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(type = family)
Craelius
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William
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internal member
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Advisory Committee
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William Craelius
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(type = family)
Wagner
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Sigurd
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outside member
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Advisory Committee
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Sigurd Wagner
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Casaccia
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Patrizia
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outside member
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Advisory Committee
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Patrizia Casaccia
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NamePart
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Ricci
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John
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(authority = RULIB)
outside member
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Advisory Committee
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John Ricci
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
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(type = degree)
2010-10
Place
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(type = code)
xx
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
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(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3CC10D2
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Langhammer
GivenName
Christopher
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-07-01 22:53:41
AssociatedEntity
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(AUTHORITY = rulib)
Role
Copyright holder
Name
Christopher Langhammer
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
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(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
(ID = RE-2);
(AUTHORITY = rulib)
Type
Embargo
DateTime
2010-10-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2011.
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application/x-tar
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4761600
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application/pdf
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