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Genes required for the oocyte-to-embryo transition in C. elegans

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TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Genes required for the oocyte-to-embryo transition in C. elegans
Identifier
ETD_2854
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056702
Language
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Cell and Developmental Biology
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Caenorhabditis elegans
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Oogenesis
Subject (ID = SBJ-4); (authority = ETD-LCSH)
Topic
Fertilization (Biology)
Abstract (type = abstract)
The reproduction of a genetically distinct organism is a delicate process, and requires, in most organisms, the faithful reproduction of a male and female gamete, which must then find one another and fuse, and then undergo the transition to developing embryo. This thesis is an examination of the molecules required for fertilization in C. elegans, emphasizing the molecules involved in the oocyte-to-embryo transition. The first chapter provides an introduction to the importance of fertility research, the general processes of fertilization with an emphasis on mammalian reproduction, the utility of C. elegans as a model organism for studying fertilization, and the basics of reproduction in C. elegans. The second chapter discusses the general processes of the oocyte-to-embryo transition in C. elegans, then outlines a module of molecules, which are known to act during this process. Particular focus is given to the elucidation of the egg-4/5 genes, which are required for coupling the oocyte-to-embryo transition to the advancement of the cell cycle. The EGG-4/5 proteins represent a new class of molecules identified as protein-tyrosine phosphatase-like, and participate in a novel method of kinase regulation. The third chapter introduces the importance of the cortical granule exocytosis during the oocyte-to-embryo transition, and later to embryogenesis. A potential new member of the cortical granules is described, egg-6, a C. elegans gene which had been identified in previous works as being necessary to osmotic integrity. Early molecular work may link the egg-6 gene to the establishment of polarity in the embryo. The fourth chapter outlines the phenotypic and partial molecular characterization of a gene required for spermiogenesis, spe-43. The process of spermiogenesis in C. elegans is not only critical to fertility, but represents a model both for differentiation without de novo protein synthesis, and for the evolutionary development of an androdioecious species from a gonochoristic one. The fifth chapter provides summary discussion the molecules discussed, and their roles in reproduction, with a particular focus on the oocyte-to-embryo transition.
PhysicalDescription
Form (authority = gmd)
electronic resource
Extent
ix, 121 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Jean Michele Parry
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Parry
NamePart (type = given)
Jean Michele
NamePart (type = date)
1983-
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author
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Jean Parry
Name (ID = NAME-2); (type = personal)
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Grant
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Barth
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chair
Affiliation
Advisory Committee
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Barth Grant
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NamePart (type = family)
Steward
NamePart (type = given)
Ruth
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internal member
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Advisory Committee
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Ruth Steward
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Rongo
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Chris
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internal member
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Advisory Committee
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Chris Rongo
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Copeland
NamePart (type = given)
Paul
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Paul Copeland
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated (qualifier = exact)
2010
DateOther (qualifier = exact); (type = degree)
2010-10
Place
PlaceTerm (type = code)
xx
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T38C9W0J
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = PRH-1); (type = personal)
Name
FamilyName
Parry
GivenName
Jean
Role
Copyright Holder
RightsEvent (ID = RE-1); (AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-09-10 11:10:37
AssociatedEntity (ID = AE-1); (AUTHORITY = rulib)
Role
Copyright holder
Name
Jean Parry
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject (ID = AO-1); (AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

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ETD
MimeType (TYPE = file)
application/pdf
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application/x-tar
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3758080
Checksum (METHOD = SHA1)
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