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Protein adsorption and bacterial adhesion on hybrid starch/polycaprolactone block copolymers
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Protein adsorption and bacterial adhesion on hybrid starch/polycaprolactone block copolymers
Identifier
ETD_2966
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056871
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Food Science
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Proteins--Synthesis
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Bacteria--Adhesion
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Block copolymers
Abstract
(type = abstract)
A wide range of block copolymers were made by changing the variables including polymer molecular weight, ratio of PCL to Starch content, di- or tri- block, linear or branched and chemical modifications on hydrophilic blocks with different chemical group. After the synthesis work, fibrinogen adsorption, Salmonella adhesion on 4 different hybrid Starch-PCL-Starch tri block copolymers and 1 poly-(ethylene glycol) (PEG)-PCL-PEG block copolymer coating surfaces were studies while PCL was the control. Besides the protein adsorption and bacterial adhesion assay, atomic force microscopy analysis (AFM), scanning electronic microscopy (SEM) and contact angle measurements were also performed to better understand the polymers’ surface properties. The surfaces were prepared by dissolving block copolymers in organic solvent followed by spin coating technique. Preliminary data showed that all the block copolymers have improved protein and bacteria repellency than PCL. Among all the block copolymers, YZ3-38 (with quaternary ammonium group), MC4-38 (substituted with N, N-diethylaminoethyl ether), MC4-44 (with hydroxypropyl groups) could dramatically improve the protein repellency, and MC4-38 and MC4-44 could significantly reduce the bacterial adhesion, compared with YZ3-14 (without modification on starch end group). MC4-38 even has comparative or better protein and bacteria repellence than PEG/PCL based copolymer (PEG is the most widely utilized protein and bacteria repellency polymer). Moreover, the data on fibrinogen adsorption, Salmonella adhesion showed that the ability to reduce fibrinogen adsorption at the copolymers surface correlates with the ability to reduce Salmonella adhesion. By evaluating the new copolymer’s surface physical, biological properties, this work is able to show the potential protein anti-adsorption and bacteria anti-adhesion properties of the PCL/Starch based copolymer and contribute to the understanding of the connections between protein adsorption, bacterial adhesion, contact angle and surface topography.
PhysicalDescription
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electronic resource
Extent
x, 61 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Peng Yuan
Name
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(type = personal)
NamePart
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Yuan
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(type = given)
Peng
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1984-
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author
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Peng Yuan
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Yam
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(type = given)
Kit
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chair
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Advisory Committee
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Kit Yam
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(type = personal)
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(type = family)
HUANG
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(type = given)
QINGRONG
Role
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internal member
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Advisory Committee
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QINGRONG HUANG
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(type = personal)
NamePart
(type = family)
Chikindas
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(type = given)
Mikhail
Role
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(authority = RULIB)
internal member
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Advisory Committee
DisplayForm
Mikhail Chikindas
Name
(ID = NAME-1);
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
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NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
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(type = degree)
2010-10
Place
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xx
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = doi)
doi:10.7282/T39023HM
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Yuan
GivenName
Peng
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-09-30 14:18:41
AssociatedEntity
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(AUTHORITY = rulib)
Role
Copyright holder
Name
Peng Yuan
Affiliation
Rutgers University. Graduate School - New Brunswick
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(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
(ID = RE-2);
(AUTHORITY = rulib)
Type
Embargo
DateTime
2010-10-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2012.
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Technical
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ETD
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application/pdf
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application/x-tar
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6236160
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