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Fabrication and characterization of low crystalline curcumin loaded lipid nanopartilcles

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TitleInfo
Title
Fabrication and characterization of low crystalline curcumin loaded lipid nanopartilcles
Name (type = personal)
NamePart (type = family)
Du
NamePart (type = given)
Yuechao
NamePart (type = date)
1985-
DisplayForm
YUECHAO DU
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Takhistov
NamePart (type = given)
Paul
DisplayForm
Paul Takhistov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Yam
NamePart (type = given)
Kit L
DisplayForm
Kit L Yam
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
DAUN
NamePart (type = given)
HENRYK
DisplayForm
HENRYK DAUN
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2011
DateOther (qualifier = exact); (type = degree)
2011-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Subject (authority = RUETD)
Topic
Food Science
Subject (authority = ETD-LCSH)
Topic
Antioxidants
Subject (authority = ETD-LCSH)
Topic
Lipids--Research
Subject (authority = ETD-LCSH)
Topic
Lipids in human nutrition
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Yuechao Du
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiii, 119 p. : ill.
Abstract (type = abstract)
Preventable chronic diseases such as cardiovascular disease, cancer account for nearly 70% of the death in the States annually. Research attributes these diseases to oxidation stress induced by free radicals. Recently, it is shown that risk of chronic diseases can be minimized by increasing intake of antioxidant. The increasing public health awareness has lead to intense need for functional food enriched with powerful antioxidants. Recent research reveals that polyphenolic compounds such as quecertin,curcumin possess great anti-oxidation and anti-cancer potential. However, enriching food with these antioxidants has been limited, because these compounds usually have poor solubility and chemically unstable. Solid lipid nanoparticles offer promising approach to deliver these hydrophobic compounds. However, it has been noted that solid lipid nanoparticles have limited loading capacity due to high crystallinity of lipid crystals. In addition, fast polymorphic transition of lipid leads to aggregation and burst release of encapsulated compound. To overcome these limitations, Nanostructured lipid carriers composed of solid lipids and liquid lipids are developed. Until recently, little research has been done on SLN and NLC for food application. In this research, food grade materials are used to fabricate SLN and NLC via ultrasonication. Curcumin, a polyphenolic antioxidant is chosen to be model compound to be encapsulated. The surface morphology of SLN and NLC are studied by dynamic light scattering and transmission electron microscope. Structure and molecular interaction of lipid nanoparticles are explored by Raman spectroscope. Differential scanning calorimetry and X-ray diffraction technique are applied to provide more insight information about crystallinity and the effect of different components on polymorphic transition of lipid nanoparticles. Research results show curcumin is encapsulated in spherical lipid nanoparticles. The encapsulation greatly improves the chemical stability of curcumin under extreme alkaline condition. Curcumin loaded SLN shows structure of curcumin enriched core with lipid shell. The average size of SLN is between 200-500nm. However, aggregation takes place shortly during storage. NLC has lower crystallinity than SLN. Lipid polymorphic transition in NLC is retarded by the addition of methyl stearate, oleic acid. In addition, smaller particles are formed in methyl stearate NLC and oleic acid NLC.
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061187
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3Z89BSD
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
DU
GivenName
YUECHAO
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2011-04-12 23:36:36
AssociatedEntity
Name
YUECHAO DU
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2011-05-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2011-11-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after November 30th, 2011.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2350080
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