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Effect of fetal alcohol on mammary carcinogenesis

Descriptive

TitleInfo
Title
Effect of fetal alcohol on mammary carcinogenesis
SubTitle
the role of the estrogen/IGF axis
TitleInfo (type = alternative)
Title
Effect of alcohol In utero on mammary carcinogenesis
SubTitle
the role of the estrogen/IGF axis
Name (type = personal)
NamePart (type = family)
Polanco
NamePart (type = given)
Tiffany
NamePart (type = date)
1982-
DisplayForm
Tiffany Polanco
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Cohick
NamePart (type = given)
Wendie S
DisplayForm
Wendie S Cohick
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Sarkar
NamePart (type = given)
Dipak
DisplayForm
Dipak Sarkar
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Katz
NamePart (type = given)
Larry
DisplayForm
Larry Katz
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Thomas
NamePart (type = given)
Paul
DisplayForm
Paul Thomas
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2011
DateOther (qualifier = exact); (type = degree)
2011-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Altered fetal programming as a result of a suboptimal in utero environment can increase disease susceptibility in adulthood. Alcohol exposure in utero increases mammary cancer risk in rodents. Mammary development affects breast cancer risk, as a denser, hyperproliferative gland increases mammary cancer risk. Therefore we hypothesized that alcohol exposure in utero increases the action of the IGF-I/E2 system leading to hyperproliferative mammary glands and ultimately increased cancer susceptibility. We first established a model where fetal alcohol leads to increased mammary tumor susceptibility. Pregnant rats were fed a liquid diet containing ethanol (alcohol-fed), a control isocaloric liquid diet, or rat chow ad libitum. Alcohol-fed dams were acclimated to increasing concentrations of ethanol (2.2% and 4.4%), then fed 6.7% ethanol from day 7 to 21 of gestation. To investigate tumorigenesis, N-nitroso-N-methlyurea (NMU) was administered to induce tumor formation at postnatal day 50. Rats were palpated for iii tumors weekly and euthanized at 23 weeks post-NMU injection, or in a second study at 16 weeks post-injection. At 16 weeks post-injection, tumor multiplicity was greater and tumor latency was decreased in the alcohol-fed group compared to controls. At 23 weeks post-NMU injection alcohol-fed animals developed more malignant tumors and more estrogen receptor-α negative tumors with less IGF binding protein-5 expression relative to controls, indicative of poor prognosis breast cancer in women. To determine if mammary development is altered by in utero alcohol exposure, a study was conducted in which animals were euthanized prepubertally and postpubertally. Mammary glands from alcohol-fed animals showed increased proliferation and aromatase expression prior to and immediately after puberty. Mammary and hepatic IGF-I mRNA levels were also higher in alcohol-fed animals. In a separate study it was determined that alcohol-fed animals also have higher circulation E2 than controls. Together, these data indicate that alcohol exposure in utero increases susceptibility to mammary tumorigenesis, and leads to a tumor phenotype indicative of poor prognosis breast cancer. These changes may be related to enhanced early mammary development via the IGF/E2 systems. Therefore, women born to mothers who drank alcohol during pregnancy may represent a high risk group for aggressive breast cancer.
Subject (authority = RUETD)
Topic
Animal Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3167
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xi, 101 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Tiffany Polanco
Subject (authority = ETD-LCSH)
Topic
Children of prenatal alcohol abuse
Subject (authority = ETD-LCSH)
Topic
Breast--Cancer--Etiology
Subject (authority = ETD-LCSH)
Topic
Alcohol--Physiological effect
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061439
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3BC3XWZ
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Polanco
GivenName
Tiffany
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2011-02-23 11:21:10
AssociatedEntity
Name
Tiffany Polanco
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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1785856
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application/pdf
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application/x-tar
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1792000
Checksum (METHOD = SHA1)
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