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Polymer based immune modulation for the generation of an anti-tumor immune response

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TitleInfo
Title
Polymer based immune modulation for the generation of an anti-tumor immune response
Name (type = personal)
NamePart (type = family)
Nikitczuk
NamePart (type = given)
Kevin P.
NamePart (type = date)
1983-
DisplayForm
Kevin Nikitczuk
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Yarmush
NamePart (type = given)
Martin
DisplayForm
Martin Yarmush
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Schloss
NamePart (type = given)
Rene
DisplayForm
Rene Schloss
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Roth
NamePart (type = given)
Charles
DisplayForm
Charles Roth
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Lattime
NamePart (type = given)
Edmund
DisplayForm
Edmund Lattime
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2011
DateOther (qualifier = exact); (type = degree)
2011-10
CopyrightDate (qualifier = exact)
2011
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Increasing emphasis is being placed on overcoming tumor-associate immune escape mechanisms that facilitate disease progression. Understanding this immune tolerance and developing methods to overcome it provide advanced understanding to further develop vaccine strategies. In the current work we have engineered a polymer based therapy that enhances cellular immunity capable of generating anti-tumor activity. We have determined that a poly(lactic-co-glycolic acid) (PLGA) based delivery system encapsulating tumor associated antigen (ovalbumin, OVA) and the TLR9 agonist CpG motif DNA can initiate an effective type 1 mediated response. Local administration of the polymer therapy on E.G7-OVA lymphoma bearing mice significantly delayed tumor progression by eliciting a strong local and systemic IFN-γ mediated anti-tumor response. It was found that this response worked independently of antigen specific CTLs, which were active in the tumor draining lymph nodes yet incapable of retarding tumor formation. In analyzing the dendritic cell response to this polymer system, it was demonstrated that this delivery system indeed increased the Th1 phenotype of dendritic cells as measured by an increase in cell surface expression of CD80, CD86 and MHCII and secretion of the cytokines IL-12 and IFN-γ. In addition, introducing the immune modulator 1-Methyl Tryptophan (1-MT) in concert with the antigen and adjuvant enhanced the dendritic cell Th1 profile when delivered via the PLGA vesicle. Taken together, these studies demonstrate the immunological mechanisms and benefits of a PLGA based delivery system.
Subject (authority = RUETD)
Topic
Biomedical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3487
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
viii, 71 p. : ill.
Note (type = degree)
Ph. D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Kevin P. Nikitczuk
Subject (authority = ETD-LCSH)
Topic
Polymeric drug delivery systems
Subject (authority = ETD-LCSH)
Topic
Tumors—Immunological aspects
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063542
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3ZK5FRS
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Nikitczuk
GivenName
Kevin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2011-08-08 13:37:29
AssociatedEntity
Name
Kevin Nikitczuk
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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