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Differential representation of drug-seeking within ventral pallidal subregions
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Root, David Hamilton. Differential representation of drug-seeking within ventral pallidal subregions. Retrieved from https://doi.org/doi:10.7282/T3BZ653J

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TitleDifferential representation of drug-seeking within ventral pallidal subregions
NameRoot, David Hamilton (author); West, Mark O (chair); Torres, Elizabeth B (internal member); Kusnecov, Alexander (internal member); Zaborszky, Laszlo (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2012
Other Date2012-01 (degree)
SubjectPsychology, Sensory neurons--Research, Cocaine--Physiological effect, Neurobiology
Extentvii, 123 p. : ill.
DescriptionVentral pallidum (VP) neurons exhibit changes in firing rate (FR) immediately prior to and/or following cocaine-reinforced responses. We first aimed to determine whether the changes in FR surrounding cocaine-seeking responses were coincident with behaviors such as approaching the manipulandum, responding on the manipulandum, and retreating away from the manipulandum. Second, we aimed to determine whether changes in FR during cocaine-seeking behaviors differed between VP subregions. Prior to recordings, animals exhibited both task and skill learning, replicating previous results using this operant. 171 single-units in the ventromedial VP (VPvm) and 48 in the dorsolateral VP (VPdl) were recorded in welltrained animals during cocaine self-administration. Baseline FR and waveform characteristics did not differ between subregions. VPdl neurons exhibited a greater absolute change in FR over VPvm neurons during approaches as well as approaches divided into cued and uncued conditions. VPdl neurons exhibited a greater absolute change in FR over the VPvm during responses as well as responses divided into those cued/reinforced and uncued/unreinforced conditions. VPdl neurons were more likely to exhibit a similar change in FR during approach and response than VPvm neurons. VPvm neurons were heterogeneous, changing FRs during approach or response alone, or both. No differences were found between subregions during retreat behavior. VPdl neurons exhibited a greater absolute change in FR over the VPvm for retreats in which the pump was activated prior to or during a retreat, but not for retreats when the pump was not activated. Given that VPdl neurons exhibited a greater change in FR than VPvm neurons during approach and response, VPdl may be involved in the expression of drug-seeking behaviors through projections to "motoric" regions such as subthalamic nucleus and substantia nigra. Furthermore, because VPdl neurons were more likely to continue their change of FR from approach through response while VPvm were more selective (e.g., approach alone, response alone), it is suggested that cocaine-seeking behaviors are differentially represented within VP subregions. The VPvm projects primarily to the mediodorsal thalamus and ventral tegmental area. Heterogeneous firing patterns within the VPvm may be involved in maintaining a representation of behavioral characteristics or sequences of self-administration behaviors.
NotePh.D.
NoteIncludes bibliographical references
Noteby David Hamilton Root
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3BZ653J
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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