Staff View
Drop on demand technology as a mini manufacturing platform for drug delivery and personalized medicine

Descriptive

TitleInfo
Title
Drop on demand technology as a mini manufacturing platform for drug delivery and personalized medicine
Name (type = personal)
NamePart (type = family)
Sahay
NamePart (type = given)
Abhishek
NamePart (type = date)
1983-
DisplayForm
Abhishek Sahay
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Takhistov
NamePart (type = given)
Paul
DisplayForm
Paul Takhistov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Shreiber
NamePart (type = given)
David
DisplayForm
David Shreiber
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Michniak
NamePart (type = given)
Bozena
DisplayForm
Bozena Michniak
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
There is need to develop a process and technology through which small tailored dosages can be delivered with precision and accuracy. This has led to research on developing a manufacturing platform which could be used to deliver personalized drugs in a variety of dosage formats both cheaply and efficiently. We envision a mini manufacturing platform centered on Drop-on-Demand (DoD) technology which can have wide ranging applications such as personalized medicine, clinical trials, poly-pharmacy and distributed manufacturing. A prototype system has been developed that has been tested for accuracy using gravimetric methods for dispensing sample dosage formats. The incorporation of online analytics has also been explored. Three sets of experiments were conducted. In the first one, the accuracy of the system was measured experimentally using gravimetric methods. The dispensing system was found to be very accurate with RSD < 1% and this was true for dispensing solutions as well as suspensions. In the second experiment the effect of viscosity was studied. It was found that for a fixed set of variables such as input pressure and nozzle diameter there was a limiting viscosity above which the dispensing was disrupted. The aggregation behavior of suspensions during flow through micro capillary was also studied. Finally the applicability of Raman spectroscopy for in line analytics was tested experimentally. It was found that Raman can be used for qualification of API in-capsule as well as in the supply line.
Subject (authority = RUETD)
Topic
Biomedical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3782
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
viii, 83 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Abhishek Sahay
Subject (authority = ETD-LCSH)
Topic
Drug delivery systems
Subject (authority = ETD-LCSH)
Topic
Pharmaceutical technology
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064169
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3GQ6WS1
Genre (authority = ExL-Esploro)
ETD graduate
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Sahay
GivenName
Abhishek
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-01-06 13:00:36
AssociatedEntity
Name
Abhishek Sahay
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

FileSize (UNIT = bytes)
8345600
Checksum (METHOD = SHA1)
7b6ab597d1e28e7cfdfb350370284226fbb644df
OperatingSystem (VERSION = 5.1)
windows xp
ContentModel
ETD
MimeType (TYPE = file)
application/pdf
Back to the top
Version 8.4.8
Rutgers University Libraries - Copyright ©2022