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Studies on Nrf2-targeted phytochemicals

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TitleInfo
Title
Studies on Nrf2-targeted phytochemicals
SubTitle
signal transduction, bioanalysis, pharmacokinetics, and pharmacodynamics for their druggability
Name (type = personal)
NamePart (type = family)
Wang
NamePart (type = given)
Hu
NamePart (type = date)
1966-
DisplayForm
Hu Wang
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Kong
NamePart (type = given)
Ah Ng Tony
DisplayForm
Ah Ng Tony Kong
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Hatefi
NamePart (type = given)
Arash
DisplayForm
Arash Hatefi
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Michniak-Kohn
NamePart (type = given)
Bozena B.
DisplayForm
Bozena B. Michniak-Kohn
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Nomeir
NamePart (type = given)
Amin A.
DisplayForm
Amin A. Nomeir
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-01
CopyrightDate (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Prevention has been regarded as a superior approach in dealing with diseases. Huang-Di Ne-Jing, a manuscript believed being written by the ancient Chinese emperor, indicated: "… the Saint treats those ill-to-be rather than those being ill" (Chapter 1, Introduction) Cancer, as it takes as long as 20 to 30 years to develop from initiated cells to malignant tumor, allows precious opportunities to prevent its occurrence and delay its progression. In the past centuries, fruitful searching for natural and synthetic cures of cancer enriched our understanding and empowered our treatment options for this disease. Phytochemicals have been sought after as handy and effective reagents for such task, along with the proposed and accepted mechanisms and pathways (Chapter 2, Plants vs. Cancer). To understand the nature of Nrf2, we studied the role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages via ex vivo approach (Chapter 3, Role of Nrf2 in inflammation suppression by DHA/EPA in mouse peritoneal macrophages). To enable further preclinical in vivo research of sulforaphane, an Nrf2 initiator and an anti-carcinogenesis agent enlisted by National Cancer Institute, a highly sensitive and robust bioanalytical method was developed, validated, and applied to the pharmacokinetic studies in rats (Chapter 4, Bioanalytical Method for Sulforaphane). A follow-up study, linking the pharmacokinetics and pharmacodynamics, enlightened how sulforaphane drives Nrf2-related gene expression of phase II drug metabolism enzymes in rat lymphocytes (Chapter 5, PK/PD studies of sulforaphane in rat following intravenous administration). From the review of the current research frontier on natural phytochemicals for cancer chemoprevention and treatment, to the Nrf2 role elucidation at the molecular level; from the bioanalytical method characterization and its application to in vivo studies, to modeling the pharmacokinetics in blood plasma and the pharmcodynamics of mRNA effects in lymphocytes, our studies contributed to the better understanding of Nrf2 and to the application potentials of the phytochemicals for their druggability. We wish to further the discovery and development research: to prevent the patients from being patients, the ultimate goal of a pharmaceutical research scientist.
Subject (authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3789
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xix, 166 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Hu Wang
Subject (authority = ETD-LCSH)
Topic
Phytochemicals--Therapeutic use--Testing
Subject (authority = ETD-LCSH)
Topic
Cancer--Treatment
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064189
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3T72GFB
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Wang
GivenName
Hu
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-01-05 21:37:03
AssociatedEntity
Name
Hu Wang
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2014-01-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 30th, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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