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Analysis of EGF signaling in healthy aging promotion in caenorhabditis elegans
Descriptive
TitleInfo
Title
Analysis of EGF signaling in healthy aging promotion in caenorhabditis elegans
Name
(type = personal)
NamePart
(type = family)
Yu
NamePart
(type = given)
Shih-Hung
NamePart
(type = date)
1977-
DisplayForm
shihhung yu
Role
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(authority = RULIB)
author
Name
(type = personal)
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(type = family)
Padgett
NamePart
(type = given)
Richard
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Richard Padgett
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Advisory Committee
Role
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Driscoll
NamePart
(type = given)
Monica
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Monica Driscoll
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Pintar
NamePart
(type = given)
John
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John Pintar
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Singson
NamePart
(type = given)
Andrew
DisplayForm
Andrew Singson
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-01
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
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(type = code)
eng
Subject
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Topic
Neuroscience
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_3769
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
xi, 251 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Shih-Hung Yu
Abstract
(type = abstract)
The increase in longevity expectancy has been a focused issue goal of much current aging research. Many genes have been noted to modulate longevity of simple model systems, acting through distinct mechanisms. However, in principle, promotion of healthy aging of individual tissues can be accomplished without a major impact on the longevity endpoint. As such, healthspan-only genes may have been missed by genetic screens for longevity. New screens for tissue–specific betterment of aging phenotypes were anticipated to reveal a class of genes that might be manipulated for tissue-specific anti-aging outcomes. We identified two novel healthspan regulators, called HPA-1 and HPA-2 (for the high performance in old age locomotory phenotypes that their disruption confers) that delay age-associated locomotory decline when they are knocked down by RNAi or by genetic deletion. Surprisingly, hpa-1 and hpa-2 do not regulate healthspan through canonical recognized longevity pathways. Instead, the structure of HPA proteins implicated a novel function of EGF signaling in anti–aging protection, and my genetic studies supported this mechanism. Activated EGF signaling confers a positive effect on multiple aging phenotypes, acting through the downstream branch of the EGF pathway involving PLCanalysis defined the temporal and spatial benefits from EGF signaling. EGF/lin-3 ligand is expressed into late life and acts throughout life to influence healthy aging. lin-3 alternative slice variants, lin-3S and lin-3XL show healthspan promotion. Muscle and neuron are the most potent tissue for EGFR signaling on healthspan enhancement. I also identified global and tissue-specific modulators of healthy aging in the EGF pathway and identified candidate calcium-sensitive transducers of the anti-aging function of EGF signaling. Recent data in vertebrates suggest that EGF signaling might contribute to long-term maintenance. Thus, EGF signaling may exert a conserved impact on healthy aging and might be a plausible reagent for anti-aging therapies.
Subject
(authority = ETD-LCSH)
Topic
Aging--Animal models
Subject
(authority = ETD-LCSH)
Topic
Aging--Endocrine aspects
Subject
(authority = ETD-LCSH)
Topic
Aging--Prevention
Subject
(authority = ETD-LCSH)
Topic
Nematodes--Aging
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064195
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3QF8RWW
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
yu
GivenName
shihhung
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2012-01-03 00:48:29
AssociatedEntity
Name
shihhung yu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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