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The glypican Dally is a target and mediator of BMP signaling in eggshell patterning
Descriptive
TitleInfo
Title
The glypican Dally is a target and mediator of BMP signaling in eggshell patterning
Name
(type = personal)
NamePart
(type = family)
Lemon
NamePart
(type = given)
David James
NamePart
(type = date)
1988-
DisplayForm
David Lemon
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Yakoby
NamePart
(type = given)
Nir
DisplayForm
Nir Yakoby
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Martin
NamePart
(type = given)
Joseph V.
DisplayForm
Joseph V. Martin
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Shain
NamePart
(type = given)
Daniel H.
DisplayForm
Daniel H. Shain
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Camden Graduate School
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Heparan sulfate proteoglycans (HSPGs) participate in the regulation of numerous cell signaling pathways in tissues throughout animal development. In Drosophila melanogaster, the HSPG Division-abnormally-delayed (Dally) acts as a co-receptor in several signaling pathways, including bone morphogenetic protein (BMP) signaling, during imaginal wing disc development. Previously, it has been shown that dally is patterned in the follicle cells (FCs), a mono-layer of epithelial cells which surrounds the oocyte. These cells derive the formation of the eggshell. We found this pattern to be evolutionary conserved across Drosophila species. Also, dally’s pattern spatially overlaps the BMP signaling domain, which was monitored by phosphorylated-Mothers-against-Dpp (P-MAD). Using genetic perturbations, we determine that in the FCs, dally is a downstream target of BMP signaling. Furthermore, in clones of cells null for dally, P-MAD is lost cell autonomously. When dally was perturbed uniformly throughout the FCs the BMP signaling gradient was expanded or restricted in gain-of-function or loss-of-function, respectively. Consequently, the FCs patterning shifted along the anterior-posterior axis. Perturbing dally in the anterior domain of the FCs resulted in changes of eggshell morphology. Specifically, the depletion of dally results in an overall increase in operculum length. Based upon our results, and consistent with Dally’s role in wing imaginal discs, we propose a model by which Dally contributes to eggshell patterning along the anterior-posterior axis by regulating BMP signaling.
Subject
(authority = RUETD)
Topic
Biology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4072
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vi, 37 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by David James Lemon
Subject
(authority = ETD-LCSH)
Topic
Bone morphogenetic proteins
Subject
(authority = ETD-LCSH)
Topic
Drosophila melanogaster--Development
Subject
(authority = ETD-LCSH)
Topic
Cell receptors
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10005600001.ETD.000064977
RelatedItem
(type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier
(type = local)
rucore10005600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T32F7MDP
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Lemon
GivenName
David
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-05-01 13:02:57
AssociatedEntity
Name
David Lemon
Role
Copyright holder
Affiliation
Rutgers University. Camden Graduate School
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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