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Predicting target release profile of antimicrobials from controlled release packaging

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TitleInfo
Title
Predicting target release profile of antimicrobials from controlled release packaging
Name (type = personal)
NamePart (type = family)
Balasubramanian
NamePart (type = given)
Aishwarya
NamePart (type = date)
1981-
DisplayForm
Aishwarya Balasubramanian
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Yam
NamePart (type = given)
Kit L
DisplayForm
Kit L Yam
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Schaich
NamePart (type = given)
Karen M
DisplayForm
Karen M Schaich
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Chikindas
NamePart (type = given)
Michael L
DisplayForm
Michael L Chikindas
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Lee
NamePart (type = given)
Dong-sun
DisplayForm
Dong-sun Lee
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract
Controlled release packaging (CRP) is an innovative technology that uses the package to deliver active compounds, such as antimicrobials in a controlled manner to enhance food safety and quality. There is an optimum range of release profiles of antimicrobial from CRP, called “Target release profile” that depends on food composition, packaging material, shelf life and temperature, to produce an effective inhibition of microbial growth for the desired shelf life. The objective of the research is to develop mathematical model to predict target release profile of antimicrobials from CRP. Target release profile is the missing link for advancing research and development in CRP. Quantifying it helps polymer scientists design packages, tailor-made for the food and shelf life requirements for effective inhibition of microorganisms under different stress conditions. This objective is achieved by quantifying the critical parameters influencing target release profile through a model system based on two hypotheses. The first hypothesis was developed to express target release profile in form of a quantifiable parameter such as diffusivity. The hypothesis was tested by generating release profile based on literature data for potassium sorbate (bacteriostatic antimicrobial) diffusivities and evaluating their effect on the growth of Escherichia coli DH5α. The results show that not all release profiles were effective in inhibiting the growth of the organisms. There was an optimum range of release profiles, thereby an optimum range of diffusivities suitable to extend the lag period of E.coli DH5α for the 24 hours period tested. Diffusivity between 7.5 x10-12 m2/s and 2.60x10-13 m2/s was needed to provide complete inhibition of the microorganism for 24 hours when 0.2 g (1 mg/mL) was added to the polymer. Increasing the amount of antimicrobial in polymer to 0.4 g and 0.6 g increased the effective range. The second hypothesis was developed to quantify the optimum diffusivity based on minimum inhibitory concentration (MIC) of the antimicrobial and its effect on microbial lag period. The hypothesis states that the release rate of antimicrobials from the package during the inherent lag period of the organism must be equal or more than their MIC to produce an effective inhibition of the organism over the desired shelf life. The results supported the hypothesis that a minimum of 0.5 mg/mL has to be delivered during the inherent lag period of E.coli DH5α. The results from the hypotheses were used to develop the target release rate model. The model is simple and takes into account the antimicrobial efficacy (MIC), microbial growth kinetics (lag period) and correlates them with the release kinetics of antimicrobial from polymer (diffusivity). The target release model was validated by evaluating the effect of nisin (bactericidal antimicrobial) release profile on the growth of Micrococcus luteus. The results validated the model and also showed that the predicted release profile was highly effective considering controlled release may use only 15% nisin to achieve complete inhibition of M. luetus rather than instant addition of 100% nisin.
Subject (authority = RUETD)
Topic
Food Science
Subject (authority = ETD-LCSH)
Topic
Anti-infective agents
Subject (authority = ETD-LCSH)
Topic
Controlled release technology
Subject (authority = ETD-LCSH)
Topic
Food--Safety measures
Subject (authority = ETD-LCSH)
Topic
Food--Packaging--Research
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3893
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xi, 126 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Aishwarya Balasubramanian
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065078
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T37M06V5
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Balasubramanian
GivenName
Aishwarya
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-04-10 08:26:36
AssociatedEntity
Name
Aishwarya Balasubramanian
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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