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Associative properties of the perirhinal network
Descriptive
TitleInfo
Title
Associative properties of the perirhinal network
Name
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(type = family)
Unal
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(type = given)
Gunes
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1986-
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Gunes Unal
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(authority = RULIB)
author
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Krekelberg
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Bart
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Bart Krekelberg
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Advisory Committee
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chair
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Pare
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Denis
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Denis Pare
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Advisory Committee
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internal member
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Creese
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(type = given)
Ian
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Ian Creese
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
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(type = family)
Koos
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(type = given)
Tibor
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Tibor Koos
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Buzsaki
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Gyorgy
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Gyorgy Buzsaki
Affiliation
Advisory Committee
Role
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(authority = RULIB)
outside member
Name
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Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - Newark
Role
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(authority = RULIB)
school
TypeOfResource
Text
Genre
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theses
Genre
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ETD doctoral
OriginInfo
DateCreated
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2012
DateOther
(qualifier = exact);
(type = degree)
2012-05
CopyrightDate
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2012
Language
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eng
Abstract
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The perirhinal cortex (PRC), comprised of Brodmann areas 35 and 36, is a rostrocaudally-oriented strip of cortex in the medial temporal lobe, whose lesion produces memory impairments. Previous in vivo recording studies have revealed that a reduction in the responsiveness of perirhinal neurons to familiar stimuli underlies object recognition memory; whereas the opposite behavior, an increase in responsiveness, is required for associative memory formation between two paired stimuli. Both phenomena rely on long-term plasticity in the PRC. However, it is currently unclear how, as a result of experience, the same network could support these two seemingly opposite forms of long-term plasticity. PRC receives topographically organized projections from many high-order neocortical areas, mostly from the adjacent temporal neocortex; and it possesses an intrinsic network that distributes these neocortical inputs throughout its rostrocaudal axis. Previous studies suggest that neocortical inputs strongly recruit perirhinal inhibitory interneurons located at the same transverse level. In contrast, distant neocortical inputs only lead to excitation because longitudinal perirhinal connections engage few inhibitory interneurons. Given these facts, it is possible that the PRC acts as a Hebbian network to associate coincident but spatially distributed inputs. Consequently, the main objective of this thesis is to shed light on the mechanisms allowing neocortical inputs to undergo long-term depression (LTD) or potentiation (LTP), depending on to what extent they recruit the intrinsic perirhinal connections. Thus, using electrophysiological and imaging techniques in the whole guinea pig brain in vitro, I show that theta-frequency stimulation (TFS) at a single neocortical site leads to an input-specific group I mGluR-dependent LTD at all perirhinal levels, whereas paired TFS of two distant neocortical sites recruits the intrinsic circuit of the PRC and results in a NMDAR-dependent LTP to the paired inputs. Consistent with these results, utilizing anterograde tracing in rats and electron microscopic observations, this thesis shows that there are more inhibitory synapses formed by direct neocortical inputs to PRC and short-range perirhinal connections compared to long-range neocortical and perirhinal axons coursing in the PRC. Together, these findings suggest a mechanism whereby PRC associates temporally relevant but spatially distributed neocortical inputs.
Subject
(authority = RUETD)
Topic
Neuroscience
Subject
(authority = ETD-LCSH)
Topic
Temporal lobes
Subject
(authority = ETD-LCSH)
Topic
Cerebral cortex--Anatomy
Subject
(authority = ETD-LCSH)
Topic
Memory disorders
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Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
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TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
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rucore10002600001
Identifier
ETD_4029
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000065065
Identifier
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doi:10.7282/T3CC0ZMZ
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electronic resource
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application/pdf
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text/xml
Extent
xiii, 121 p. : ill.
Note
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Ph.D.
Note
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Includes bibliographical references
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Includes vita
Note
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by Gunes Unal
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Unal
GivenName
Gunes
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2012-04-25 15:45:15
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Name
Gunes Unal
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Affiliation
Rutgers University. Graduate School - Newark
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Type
License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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