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Development and validation of an improved method for determination of chloropropanols in paperboard food packaging by GC-MS
Descriptive
TitleInfo
Title
Development and validation of an improved method for determination of chloropropanols in paperboard food packaging by GC-MS
Name
(type = personal)
NamePart
(type = family)
Liu
NamePart
(type = given)
Wan-yun
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Wan-yun Liu
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Hartman
NamePart
(type = given)
Thomas G.
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Thomas G. Hartman
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Schaich
NamePart
(type = given)
Karen M.
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Karen M. Schaich
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
HO
NamePart
(type = given)
CHI-TANG
DisplayForm
CHI-TANG HO
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Paper used for food packaging is often manufactured with wet strength resin additives to impart moisture resistance. Wet strength resins formulated with epichlorohydrin form undesirable chloropropanol type by-products including 3-chloro-1,2-propanediol (3-MCPD) and 1,3-dichloro-2-propanol(1,3-DCP). Chloropropanols are suspect carcinogens. These compounds were recently added to the California Proposition 65 list (known or suspect human carcinogens) which mandates labeling of products sold in the state of California, creating a dilemma for food packaging processors. Food packaging manufacturers are concerned with migration of chloropropanols from packaging into foods or beverages. Therefore, analytical methods for determination of chloropropanols in paperboard food packaging are of great importance. However, previously described methods are not developed for paperboard food packaging samples, or not for EU standard aqueous extraction study of paperboard samples. The objective of this research is to develop an improved analytical method for determination of 3-MCPD and 1,3-DCP in paper type food packaging. The refined method uses aqueous extraction, matrix-spiking of a deuterated surrogate internal standard (3-MCPD-d5), cleanup using Extrelut solid phase extraction, derivatization using silylation reagent, and GC-MS analyses of the chloropropanols as their corresponding trimethyl silyl ethers. The new method is applicable to paper type food packaging sample for EU standard aqueous extraction study and aqueous food stimulant migration test. Also, the method uses 10 times less sample size, solvents and reagents than previously described methods, reducing the cost and time for analysis. The derivatization procedure was also improved. The overall validation data suggest the method is precise and rugged. The limit of detection of aqueous extract is 0.010 ppm (w/w) for both 3-MCPD and 1,3-DCP. Analytical system precision is 3.36%RSD for 3-MCPD and 7.65%RSD for 1,3-DCP. The new method has been applied to the analysis of over 100 commercial paperboard packaging samples. The data is being used to guide development of next generation wet strength resins with reduced chloropropanols content, and also used for risk assessments to calculate VSD (virtual safe dose).
Subject
(authority = RUETD)
Topic
Food Science
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_3934
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xi, 80 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Wan-yun Liu
Subject
(authority = ETD-LCSH)
Topic
Food--Packaging
Subject
(authority = ETD-LCSH)
Topic
Packaging--Research
Subject
(authority = ETD-LCSH)
Topic
Package goods industry
Subject
(authority = ETD-LCSH)
Topic
Allyl chloride
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065197
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3542MHZ
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Liu
GivenName
Wan-yun
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2012-04-12 18:11:33
AssociatedEntity
Name
Wan-yun Liu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2012-05-31
DateTime
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(qualifier = exact);
(point = end)
2013-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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2776064
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windows xp
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ETD
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application/pdf
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application/x-tar
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2785280
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