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The effects of resolvins on dermal wound healing
Descriptive
TitleInfo
Title
The effects of resolvins on dermal wound healing
Name
(type = personal)
NamePart
(type = family)
Menon
NamePart
(type = given)
Riyesh
NamePart
(type = date)
1986-
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Riyesh Menon
Role
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(authority = RULIB)
author
Name
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Shreiber
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David
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David Shreiber
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Advisory Committee
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chair
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Berthiaume
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Francois
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Francois Berthiaume
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Advisory Committee
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internal member
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(type = personal)
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(type = family)
Silver
NamePart
(type = given)
Fred
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Fred Silver
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Cai
NamePart
(type = given)
Li
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Li Cai
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
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Text
Genre
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theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
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(type = degree)
2012-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
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(type = code)
eng
Subject
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Topic
Biomedical Engineering
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD_3935
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electronic resource
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application/pdf
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text/xml
Extent
x, 78 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Riyesh Menon
Abstract
(type = abstract)
A classical skin wound healing model can be divided into four distinct phases – instantaneous response, inflammatory, proliferation and the final remodeling phase. The balance between stimulatory and inhibitory mediators in each of these phases is critical in achieving optimal and efficient wound closure. It is well understood that inefficient or untimely resolution of inflammatory responses can result in profound delay in wound closure and increased tissue scarring as in the case with chronic wounds. This thesis studies the impact of exogenous administration of different types of pro inflammation resolution compounds such as Resolvin E1 (RvE1), Resolvin D1 (RvD1) and Resolvin D2 (RvD2) on dermal wound healing mechanism. In vitro migration assay studies performed using neutrophil cells confirmed the pro-resolution behavior of Resolvin compounds. All Resolvin compounds significantly blocked chemoattractant (fMLP) stimulated neutrophil migration. RvE1 demonstrated significantly better potency to block fMLP simulated neutrophil migration as compared to RvD1 and RvD2. This behavior was dose dependent and more pronounced at a concentration of 2000nM. Dorsal full thickness wound studies on wild type mice were performed using skin substitute (Integra Dermal Regenerative® Skin or Alloderm® Regenerative Tissue Matrix) along with administration of 2000nM Resolvin at the wound site. Results from the study revealed that complete wound closure time significantly reduced from 28.6±1.52 days (control) to 19.4±1.52 days with RvE1 treatment, 22.8±1.79 days with RvD2 treatment and 24.4±2.19 days with RvD1 treatment (n=5, p<0.05). Histology of wounds treated with RvE1 at Day 30 revealed a well-structured and repaired site with organized layers of dense collagen and a completely re-epithelized surface as compared to the saline treated wounds (control). These results demonstrate that the addition of Resolvins to a wound site significantly accelerates the wound healing and re-epithelialization process.
Subject
(authority = ETD-LCSH)
Topic
Skin--Wounds and injuries--Treatment
Subject
(authority = ETD-LCSH)
Topic
Anti-inflammatory agents
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065220
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3639NP7
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Menon
GivenName
Riyesh
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2012-04-12 20:17:50
AssociatedEntity
Name
Riyesh Menon
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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2012-05-31
DateTime
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2012-11-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after November 30th, 2012.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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2425856
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2426880
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