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Multifunctional biosensors using ZnO and its nanostructures
Descriptive
TitleInfo
Title
Multifunctional biosensors using ZnO and its nanostructures
Name
(type = personal)
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Reyes
NamePart
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Pavel Ivanoff
NamePart
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1974-
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Pavel Ivanoff Reyes
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(authority = RULIB)
author
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(type = personal)
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Lu
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(type = given)
Yicheng
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Yicheng Lu
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Advisory Committee
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chair
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Lai
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Warren
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Warren Lai
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Advisory Committee
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internal member
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(type = family)
Jiang
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(type = given)
Wei
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Wei Jiang
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Advisory Committee
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internal member
Name
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(type = family)
Jeon
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(type = given)
Jaeseok
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Jaeseok Jeon
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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(type = family)
Boustany
NamePart
(type = given)
Nada
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Nada Boustany
Affiliation
Advisory Committee
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(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
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(authority = RULIB)
degree grantor
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Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated
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2012
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(type = degree)
2012-05
CopyrightDate
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2012
Place
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xx
Language
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eng
Abstract
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In recent years, biosensors research has emerged as a major field in both academic institutes and industries with broad applications in drug discovery and development, clinical diagnostic tools, cancer and genetic research, agricultural and veterinary analysis, pollution and contamination monitoring, and food processing. ZnO is a wide band gap semiconductor with unique multifunctional material properties, which is particularly attractive for sensor technology. ZnO can be grown as thin films or as nanostructures with different morphologies on various substrates. Through proper doping, ZnO and its ternary MgxZn1-xO can be made transparent and conductive, piezoelectric, or ferromagnetic. ZnO-based sensors have demonstrated high sensitivity to various organic and inorganic gases and liquids. The biocompatibility of ZnO is demonstrated in detections of proteins, antibodies, and DNA through the proper surface functionalization. The control of the surface wettability of ZnO nanotips between super-hydrophilic and super-hydrophobic states are used to dramatically enhance the sensitivity of ZnO-based biosensors. The aim of this work is to create new paradigms in sensor technology through novel manipulation of nanometer-scale ZnO surfaces and structures, advancement of ZnO-based multi-modal sensing (e.g., acoustic, electrical, and optical). The new sensor technology is based on combination of accurate and high quality growth of multifunctional ZnO single crystal nanostructure arrays, organic and biomolecular functionalization of ZnO surfaces, and design and development of sensor platforms and devices. The key results of this research features the following sensors and their specific applications: (i) ZnO nanostructure-modified thin film bulk acoustic wave resonator (ZnOnano-TFBAR) for DNA detection, (ii) ZnO nanostructure-modified quartz crystal microbalance (ZnOnano-QCM) for dynamic and noninvasive monitoring of bovine aortic endothelial cells (BAEC), (iii) sensor-on-food packaging based on ZnO surface acoustic wave (SAW) sensor built on protein-coated flexible substrates, and (iv) ZnO thin film transistor immunosensor (ZnO-bioTFT) for detection of epithelial growth factor receptor (EGFR) proteins found in breast cancer cells. The new ZnO sensor technology presents great impact on the future classes of multi-modal and multifunctional biosensors and biochips for applications such as cell-based assay development, smart food packaging, and high throughput biosensor arrays that perform highly sensitive and selective biochemical detection.
Subject
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Topic
Electrical and Computer Engineering
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD_3979
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electronic resource
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application/pdf
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Extent
xvii, 119 p. : ill.
Note
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Ph.D.
Note
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Includes bibliographical references
Note
(type = statement of responsibility)
by Pavel Ivanoff Reyes
Subject
(authority = ETD-LCSH)
Topic
Biosensors
Subject
(authority = ETD-LCSH)
Topic
Nanostructured materials
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065254
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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doi:10.7282/T3WS8S6B
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ETD doctoral
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Reyes
GivenName
Pavel Ivanoff
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2012-04-16 02:10:03
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Name
Pavel Ivanoff Reyes
Role
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Affiliation
Rutgers University. Graduate School - New Brunswick
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License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2012-05-31
DateTime
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2014-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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