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Physical models designed for vascular stenosis and fluid dynamic studies
Descriptive
TitleInfo
Title
Physical models designed for vascular stenosis and fluid dynamic studies
Name
(type = personal)
NamePart
(type = family)
Rodas
NamePart
(type = given)
Monica Michelle
NamePart
(type = date)
1985-
DisplayForm
Monica Rodas
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Drzewiecki
NamePart
(type = given)
Gary M.
DisplayForm
Gary M. Drzewiecki
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Li
NamePart
(type = given)
John K-J.
DisplayForm
John K-J. Li
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Craelius
NamePart
(type = given)
William
DisplayForm
William Craelius
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Atherosclerosis and Cardiovascular disease make up the leading cause of death in the United States. The disease occurs when plaque develops on lesions in the arterial lumen causing narrowing and hardening of the vessel walls. When the lumen cross-sectional area continues to decrease, the velocity of blood increases eventually becoming turbulent. This blood flow turbulence is believed to produce a sound in the occluded artery known as a bruit. Carotid auscultations are considered the golden standard for stenosis screening. However, recent studies suggest this is a poor predictor of carotid stenosis (sensitivity: 11% -51%). There are inaccuracies in relationships between vascular bruits and severity of the disease. Bruits can be missed due to loud sounds produced in the arteries and may be out of the range of human hearing. Therefore, an understanding of the fluid dynamics of diseased arteries will provide more accurate noninvasive methods for detecting and classifying arterial stenosis. This thesis proposes that physical models may be used to simulate the fluid dynamics of the diseased artery. In this research, experiments were conducted on three physical models that represent different geometries of stenosis. The models consisted of latex tubing with a bending modulus and cross-sectional area similar to a carotid artery in situ. A constant mean flow was passed through the lumen of the models, and the wall displacements and sounds produced were obtained and analyzed. The recording devices consisted of a piezoelectric material, optical sensor, and electronic stethoscope. The results show that stenosis facing a flexible wall produces greater wall vibrations than a symmetrical rigid stenosis. It was found that increasing the length of a plaque dome results in higher frequencies. The Continuous Wavelet Transforms (CWTs) of the measurements showed that stenosis with rigid symmetry reduces the amount of wall motion and sounds produced in time. The models have shown that wall motion is affected by stenotic geometries and thus provides a useful approach to the study of fluid dynamics of vascular disease. These relationships can be used to increase the sensitivity of classifying and detecting the structure of stenosis using noninvasive devices.
Subject
(authority = RUETD)
Topic
Biomedical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_3829
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xii, 76 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Monica Michelle Rodas
Subject
(authority = ETD-LCSH)
Topic
Carotid artery--Stenosis--Research
Subject
(authority = ETD-LCSH)
Topic
fluid dynamics--Research
Subject
(authority = ETD-LCSH)
Topic
Cardiovascular system--Diseases--Diagnosis
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065257
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T39022QW
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Rodas
GivenName
Monica
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-04-06 14:35:02
AssociatedEntity
Name
Monica Rodas
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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5113344
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windows xp
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ETD
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application/pdf
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5120000
Checksum
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