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Microfluidic continuous flow immunoassay for autonomous measurement of inflammation markers in a native sample stream
Descriptive
TitleInfo
Title
Microfluidic continuous flow immunoassay for autonomous measurement of inflammation markers in a native sample stream
Name
(type = personal)
NamePart
(type = family)
Sasso
NamePart
(type = given)
Lawrence A.
NamePart
(type = date)
1980-
DisplayForm
Lawrence Sasso
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Zahn
NamePart
(type = given)
Jeffrey D
DisplayForm
Jeffrey D Zahn
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Lee
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(type = given)
KiBum
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KiBum Lee
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Androulakis
NamePart
(type = given)
Ioannis
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Ioannis Androulakis
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Undar
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(type = given)
Akif
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Akif Undar
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-05
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
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(type = code)
eng
Abstract
(type = abstract)
A microfluidic device is presented which fully automates all of the incubation steps of a microbead immunoassay. The device requires only controlled inlet flow rates to achieve this automation, and has no moving parts. These assays are useful for a wide variety of biomolecular quantification applications. Additional benefits of the micro-immunoassay are small sample volume requirements, high sampling rate capability, continuous monitoring, and the potential for real time monitoring of time-varying sample concentrations. The continuous monitoring feature has specific clinical applications such as studying the time course of inflammatory biomarkers in the blood during mechanical circulatory support procedures, and studying the inflammation response in cerebrospinal fluid following spinal cord injury. It has also been shown that multiplexed quantification on a single micro-immunoassay chip is possible. These unique features will enable a variety of new functionalities for clinical diagnostics and laboratory research as compared to existing assay techniques.
Subject
(authority = RUETD)
Topic
Biomedical Engineering
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_3713
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xvii, 115 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Lawrence A. Sasso Jr.
Subject
(authority = ETD-LCSH)
Topic
Microfluidic devices
Subject
(authority = ETD-LCSH)
Topic
Microfluidics
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065261
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3P849T2
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Sasso
GivenName
Lawrence
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2011-11-30 11:15:05
AssociatedEntity
Name
Lawrence Sasso
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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3026432
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windows xp
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3031040
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Statistical Profile