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Absorption and oral bioavailability of nanoencapsulated curcumin

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TitleInfo
Title
Absorption and oral bioavailability of nanoencapsulated curcumin
Name (type = personal)
NamePart (type = family)
Yu
NamePart (type = given)
Hailong
NamePart (type = date)
1982-
DisplayForm
Hailong Yu
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
QINGRONG
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QINGRONG HUANG
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Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
HO
NamePart (type = given)
CHI-TANG
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CHI-TANG HO
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Lee
NamePart (type = given)
Tung-Ching
DisplayForm
Tung-Ching Lee
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
MOU-TUAN
DisplayForm
MOU-TUAN HUANG
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-05
CopyrightDate (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Many natural bioactive compounds bear various health-promoting benefits and are incorporated in functional foods. The utilization of the compounds in human body, or the bioavailability is usually not taken into consideration in the process of food formulation. In this Ph.D. study, the problem of the poor bioavailability of polyphenols, such as curcumin, was addressed by development of two nanoscale delivery systems, namely biopolymer micelles and nanoemulsions. It is known that solubilization and metabolism are two limiting factors for curcumin oral bioavailability. Using Caco-2 cell monolayers model, it was revealed that the permeation of solubilized curcumin was fast and by passive diffusion and that solubilization, not permeation of curcumin limited the absorption and the oral bioavailability. Subsequently, the solubilization of curcumin was improved by encapsulation of curcumin in biopolymer-based micelles and organogel-based formulations. Polymer micelles were generated from modified starch and self-synthesized modified epsilon polylysine. Upon encapsulation, the water solubility of curcumin was greatly increased and curcumin was stabilized against alkaline degradation. Moreover, the in vitro anti-cancer and cellular antioxidant activities of curcumin were also enhanced. On the other hand, food-grade curcumin organogel with high loading and in vitro bioaccessibility was developed. Based on the organogel, nanoemulsions were further generated to achieve faster and more complete digestion. The absorption mechanism of the nanoemulsion was examined using Caco-2 cell monolayer permeation assay and was suggested as the classic digestion-permeation route. It was further revealed that the oral bioavailability increased by 9-fold compared with unformulated curcumin on mice. Moreover, the toxicity of nanoemulsions was examined in vitro. Three tested food-grade nanoemulsions did not show significant toxicity on Caco-2 cell monolayers, which suggested that nanoemulsions may not affect the integrity of the small intestine epithelium. The biopolymer micelles and nanoemulsion formulations can be applied for oral delivery of other water-insoluble compounds for functional food application. And the formulation development method driven by absorption mechanisms also provides an example for future formulation studies.
Subject (authority = RUETD)
Topic
Food Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3827
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xviii, 213 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Hailong Yu
Subject (authority = ETD-LCSH)
Topic
Polyphenols--Bioavailability
Subject (authority = ETD-LCSH)
Topic
Nanotechnology
Subject (authority = ETD-LCSH)
Topic
Nanoelectromechanical systems
Subject (authority = ETD-LCSH)
Topic
Polyphenols--Absorption and adsorption
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065302
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T35D8QRC
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Yu
GivenName
Hailong
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-01-18 22:18:36
AssociatedEntity
Name
Hailong Yu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-05-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2013-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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