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Ischemic-hypoxic perinatal conditions and attention deficit hyperactivity disorder

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TitleInfo
Title
Ischemic-hypoxic perinatal conditions and attention deficit hyperactivity disorder
Name (type = personal)
NamePart (type = family)
Getahun
NamePart (type = given)
Darios
NamePart (type = date)
1963-
DisplayForm
Darios Getahun
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Rhoads
NamePart (type = given)
George G
DisplayForm
George G Rhoads
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
DEMISSIE
NamePart (type = given)
KITAW
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KITAW DEMISSIE
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Lu
NamePart (type = given)
Shou-En
DisplayForm
Shou-En Lu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Jacobsen
NamePart (type = given)
Steven J
DisplayForm
Steven J Jacobsen
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder in the nation affecting 8%-13% of all school-aged children. ADHD diagnoses have reached epidemic proportions in the U.S. with an estimated annual cost of $36 to $52.4 billion, in 2005 dollars. The etiology of ADHD is largely unknown. Emerging evidence suggests that Ischemic-hypoxic conditions (IHC) have profound effects on fetal brain development that are not apparent in infants. Given that rates of ADHD are increasing and IHC increases the risk of fetal brain injury, we hypothesize that IHCs are important and independent risk factor for ADHD. In this nested case-control study, we evaluated the risk of ADHD in a cohort of children aged 5-11 years, born at ≥28 weeks of gestation, and cared for at Kaiser Permanente Southern California (KPSC) between 1995-2010 (n =308,634; 4.3% had ADHD). Electronic clinical, laboratory, and pharmacy records were obtained for these children and their mothers. Cases were children with a clinical diagnosis of ADHD (ICD-9 codes 314.x) and positive for at least 2 ADHD prescriptions during the follow-up period. For each case, five controls were matched to cases on child age at diagnosis. IHC was defined based on ICD-9 codes. Compared to control children, case children were more likely to be male and of white or black race/ethnicity. Mothers of case children were more likely to be older, have ≥12 years education, history of smoking and psychosocial disorders during pregnancy. In contrast to control children, case children were more likely (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.11, 1.21) to experience IHC. Stratified analyses by gestational age revealed that case children than controls were more likely to experience IHC at 28-33 (OR 1.5, 95% CI 1.2, 2.0), 34-36 (OR 1.2, 95% CI 1.1, 1.5), and 37-42 (OR 1.1, 95% CI 1.0, 1.2) weeks of gestation. IHC was associated with increased odds of ADHD across all race/ethnicity groups. These findings suggest that IHC is an independent risk factor for ADHD, especially in preterm birth. This suggests that events in pregnancy contribute to the etiology of this condition over and above the well-known familial/genetic influences.
Subject (authority = RUETD)
Topic
Public Health
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3898
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 93 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Darios Getahun
Subject (authority = ETD-LCSH)
Topic
Ischemia
Subject (authority = ETD-LCSH)
Topic
Cerebral ischemia
Subject (authority = ETD-LCSH)
Topic
Fetus--Development
Subject (authority = ETD-LCSH)
Topic
Brain--Abnormalities
Subject (authority = ETD-LCSH)
Topic
Attention-deficit hyperactivity disorder
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065142
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3PK0F3W
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Getahun
GivenName
Darios
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-04-10 16:27:02
AssociatedEntity
Name
Darios Getahun
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-05-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2014-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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780288
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application/pdf
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application/x-tar
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