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Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia
Descriptive
TitleInfo
Title
Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia
Name
(type = personal)
NamePart
(type = family)
Khavulya
NamePart
(type = given)
Dmitry
NamePart
(type = date)
1980-
DisplayForm
Dmitry Khavulya
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Li
NamePart
(type = given)
John J-K.
DisplayForm
John J-K. Li
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Drzewiecki
NamePart
(type = given)
Gary M.
DisplayForm
Gary M. Drzewiecki
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
co-chair
Name
(type = personal)
NamePart
(type = family)
Shoane
NamePart
(type = given)
George K.
DisplayForm
George K. Shoane
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
co-chair
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
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2012
DateOther
(qualifier = exact);
(type = degree)
2012-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The brain is critically dependent on blood flow and oxygen supply for its normal function. Few existing methods allow rapid noninvasive assessment during critical hypoxic events. A novel technique for recording and analyzing brain auditory evoked potential (BAEP) under hypoxic conditions was developed. Experiments were performed on a healthy subject during hyperventilation (HV) and episodes of periodic breath-holding. Surface electrodes were used to measure EEG (electro-encephalogram) and also BAEP in A2-Cz configuration. Auditory stimuli were applied in the form of 0.1 seconds stream of clicks. An analog circuit and data acquisition system was developed for amplifying, filtering and recording the EEG from Cz-A2 position. Data were digitized online. Signal processing techniques were performed to extract and analyze BAEP using Latency Correction (LC), Ensemble Averaging, Continuous Wavelet Transform (CWT), and Principal Component Analysis (PCA). Results showed that the hypoxic conditions caused depolarization and hyperpolarization, producing aggregate potentials or field potentials. BAEPs can be extracted and analyzed under hypoxic conditions with minimum averaging (400 realizations) allowing real time evaluation of the auditory pathway. Increased activity in the auditory pathway directly following depletion of oxygen to the brain was observed. The hypoxic condition was confirmed when BAEP was used in combination with a near-infrared spectroscopic device for quantifying oxygenation. Thus, the BAEP system designed here can be used for non-invasive, real-time assessment of the auditory pathway, in identifying abnormal breathing and hypoxic events, and in the evaluation of patients suffering from cerebrospinal injury when used in conjunction with near-infrared oxygenation monitoring system.
Subject
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Topic
Biomedical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_3921
PhysicalDescription
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
ix, 92 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Dmitry Khavulya
Subject
(authority = ETD-LCSH)
Topic
Blood flow--Measurement
Subject
(authority = ETD-LCSH)
Topic
Auditory evoked response
Subject
(authority = ETD-LCSH)
Topic
Brain
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065171
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3Z31XMF
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Khavulya
GivenName
Dmitry
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-04-12 10:19:22
AssociatedEntity
Name
Dmitry Khavulya
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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7963136
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application/pdf
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application/x-tar
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7966720
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