Staff View
Prognosis for Survival of Young Women with Breast Cancer by Quantitative p53 Immunohistochemistry

Descriptive

TypeOfResource
Text
TitleInfo
Title
Prognosis for Survival of Young Women with Breast Cancer by Quantitative p53 Immunohistochemistry
Name (type = personal)
NamePart (type = family)
Axelrod
NamePart (type = given)
David E.
Affiliation
Genetics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Shah
NamePart (type = given)
Kinsuk
Affiliation
Genetics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yang
NamePart (type = given)
Qifeng
Affiliation
Dept. of Radiation Oncology, Robert Wood Johnson Medical School-UMDNJ, Cancer Institute of New Jersey
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Haffty
NamePart (type = given)
Bruce G.
Affiliation
Dept. of Radiation Oncology, Robert Wood Johnson Medical School-UMDNJ, Cancer Institute of New Jersey
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Genetics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Name (type = corporate)
NamePart
National Institutes of Health
Role
RoleTerm (authority = marcrelator); (type = text)
Sponsor
Name (type = corporate)
NamePart
Breast Cancer Research Foundation
Role
RoleTerm (authority = marcrelator); (type = text)
Sponsor
Name (type = corporate)
NamePart
National Natural Science Foundation of China
Role
RoleTerm (authority = marcrelator); (type = text)
Sponsor
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2012
Publisher
Canadian Center of Science and Education
Abstract
p53 protein detected immunohistochemically has not been accepted as a biomarker for breast cancer patients because of disparate reports of the relationship between the amount of p53 protein detected and patient survival. The purpose of this study was to determine experimental conditions and methods of data analysis for which p53 stain intensity could be prognostic for survival of young breast cancer patients. A tissue microarray of specimens from 93 patients was stained with anti-p53 antibody, and stain intensity measured with a computer-aided image analysis system. A cut-point at one standard deviation below the mean of the distribution of p53 stain intensity separated patients into two groups with significantly different survival. These results were confirmed by Quantitative Nuclear Grade determined by DNA-specific Feulgen staining. P53 provided information beyond ER and PR status. Therefore, under the conditions reported here, p53 protein can be an effective prognostic factor for young breast cancer patients.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
13 p.
RelatedItem (type = host)
TitleInfo
Title
Axelrod, David
Identifier (type = local)
rucore30017800001
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Center for the Development of a Virtual Tumor
AssociatedEntity
Role
Originator
Name
David E. Axelrod
AssociatedEntity
Role
Originator
Name
Kinsuk Shah
AssociatedObject
Type
Grant number
Name
U56 CA113004
Detail
DEA and KS were supported by National Institutes of Health grant U56 CA113004.
Extension
DescriptiveEvent
Type
Grant award
Detail
BH was supported by the Breast Cancer Research Foundation
AssociatedEntity
Role
Funder
Name
Breast Cancer Research Foundation
AssociatedEntity
Role
Originator
Name
Bruce G. Haffty
Extension
DescriptiveEvent
Type
Grant award
Detail
QY was supported by the National Natural Science Foundation of China (No. 81172529)
AssociatedEntity
Role
Funder
Name
National Natural Science Foundation of China
AssociatedEntity
Role
Originator
Name
Qifeng Yang
AssociatedObject
Type
Grant number
Name
No. 81172529
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2012
AssociatedObject
Type
Journal
Relationship
Has part
Name
Cancer and Clinical Oncology
Identifier (type = volume and issue)
1(1)
Reference (type = digital)
http://dx.doi.org/10.5539/cco.v1n1p52
Detail
52-64
Subject (authority = LCSH)
Topic
Breast--Cancer
Subject (authority = LCSH)
Topic
p53 protein
Subject (authority = LCSH)
Topic
Prognosis
Subject (authority = LCSH)
Topic
Biochemical markers
Subject (authority = LCSH)
Topic
Image analysis
Subject (authority = local)
Topic
Survival
Subject (authority = local)
Topic
Tissue microarray
Subject (authority = local)
Topic
Biomarker
Subject (authority = local)
Topic
Nuclear grade
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore30017800001.Manuscript.000066410
Identifier (type = doi)
doi:10.7282/T3BR8QJP
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Back to the top

Rights

RightsHolder (type = personal)
Name
FamilyName
Axelrod
GivenName
David E.
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Shah
GivenName
Kinsuk
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Yang
GivenName
Qifeng
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Haffty
GivenName
Bruce G.
Role
Copyright holder
RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Submission agreement v. 1
Detail
I am submitting my own manuscript:Grant Compliance - I am submitting an electronic version of my final manuscript that is the result of research supported, in whole or in part, with direct costs by the National Institutes of Health. This submission is voluntary and fulfills the existing requirement to provide publications as part of NIH project progress reports. Public Release - I permit public release of this manuscript via PubMed Central available after any applicable embargo period prescribed by the journal in which it appeared. Copyright Compliance - This public release permission is consistent with any copyright agreement about this manuscript that I have made with the journal publisher.
Back to the top

Technical

ContentModel
Manuscript
MimeType (TYPE = file)
application/pdf
MimeType (TYPE = container)
application/x-tar
FileSize (UNIT = bytes)
430080
Checksum (METHOD = SHA1)
dda9ea993deb40b453379afb7a5f179c9dbbc461
Back to the top
Version 8.3.10
Rutgers University Libraries - Copyright ©2019