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The effect of interleukin 17 on oligodendrocyte proliferation and differentiation
Descriptive
TitleInfo
Title
The effect of interleukin 17 on oligodendrocyte proliferation and differentiation
Name
(type = personal)
NamePart
(type = family)
Tetteh
NamePart
(type = given)
Sandra
DisplayForm
Sandra Tetteh
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Kim
NamePart
(type = given)
Haesun
DisplayForm
Haesun Kim
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Kim
NamePart
(type = given)
Haesun A
DisplayForm
Haesun A Kim
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Jonakait
NamePart
(type = given)
Gene Miller
DisplayForm
Gene Miller Jonakait
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
co-chair
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
Place
PlaceTerm
(type = code)
xx
CopyrightDate
(qualifier = exact)
2012
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Interleukin-17 (IL-17) is a cytokine that may cross the blood-brain barrier to promote inflammation and participate in the formation of lesions in patients with multiple sclerosis, where recurrent inflammatory attacks lead to oligodendrocyte loss, loss of axons, and ensuing neurological infirmities. Studies have indicated that the levels of IL-17 mRNA are elevated in the cerebrospinal fluid of multiple sclerosis (MS) patients, and microarray analysis of MS lesions show elevated levels of IL-17 transcripts. In this study we set up an in vitro system to examine the role of IL-17 on oligodendrocyte precursor cell (OPC) proliferation and their differentiation into mature oligodendrocytes (OLs). OPCs were treated with increasing doses of IL-17 (0.03 nM, 0.1 nM, 0.3 nM, 0.9 nM) in the presence of PDGF and FGF, and the effect on proliferation was assessed by BrdU uptake. The results show that while IL-17 alone had nominal mitogenic effect on OPCs it promoted growth factor induced proliferation (p<0.0001). Interestingly, the effect on proliferation was only seen at low doses of IL-17, whereas at high doses, the cytokine inhibited OPC proliferation. IL-17 did not have any significant effect on OPC differentiation in culture. All together these results show a dose-dependent effect by IL-17 on OPC proliferation. Additional experiments will be important to further elucidate the role of IL-17 on the oligodendrocyte lineage formation.
Subject
(authority = RUETD)
Topic
Biology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4319
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
v, 48 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Sandra Tetteh
Subject
(authority = ETD-LCSH)
Topic
Interleukins
Subject
(authority = ETD-LCSH)
Topic
Multiple sclerosis--Research
Subject
(authority = ETD-LCSH)
Topic
Multiple sclerosis--Complications
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066589
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3S18192
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Tetteh
GivenName
Sandra
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-09-28 12:32:28
AssociatedEntity
Name
Sandra Tetteh
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
FileSize
(UNIT = bytes)
1060864
OperatingSystem
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windows xp
ContentModel
ETD
MimeType
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application/pdf
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application/x-tar
FileSize
(UNIT = bytes)
1064960
Checksum
(METHOD = SHA1)
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