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Development and characterization of lipid based nanosystems of quercetin for topical delivery
Descriptive
TitleInfo
Title
Development and characterization of lipid based nanosystems of quercetin for topical delivery
Name
(type = personal)
NamePart
(type = family)
Bose
NamePart
(type = given)
Sonali
NamePart
(type = date)
1973-
DisplayForm
Sonali Bose
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Michniak-Kohn
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(type = given)
Bozena
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Bozena Michniak-Kohn
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Minko
NamePart
(type = given)
Tamara
DisplayForm
Tamara Minko
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
You
NamePart
(type = given)
Guofeng
DisplayForm
Guofeng You
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Ruegger
NamePart
(type = given)
Colleen E
DisplayForm
Colleen E Ruegger
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The presence of large amounts of reactive oxygen species (ROS) leads to oxidative stress that can damage cell membranes, lead to DNA breakage and inactivation of free radical scavenger enzymes, eventually resulting in skin damage. The natural flavonoid quercetin (3, 3’, 4’, 5,7-pentahydroxyflavone) has been shown to have the highest anti-radical activity, along with the ability to act as a scavenger of free radicals and an inhibitor of lipid peroxidation. In this research work, lipid based nanosystems of quercetin have been developed using lipids and surfactants considered acceptable in topical formulations and evaluated for topical delivery of quercetin. Systematic screening of the formulation and process parameters led to the development of a physically stable solid lipid (glyceryl dibehenate) based nanosystem using a probe ultrasonication method. Further optimization of the formulation included substitution of a part of the solid lipid (glyceryl dibehenate) with a liquid lipid (oleic acid) to generate nanostructured lipid carriers (NLC). High pressure homogenization, a method widely used in the pharmaceutical industry to generate nanoparticles, was also evaluated as a manufacturing process for these lipid based nanosystems. Transmission electron microscopy (TEM) studies showed spherical particles in the nanometer range for all the systems. XRD scans indicated the onset of a partial transformation of glyceryl behenate from the metastable β’ to the more stable βi form for all formulations. In vitro release studies showed a biphasic release profile, characterized by an initial burst release followed by a more controlled release pattern. Skin permeation studies using full thickness human skin showed a statistically significant increase in the amount of quercetin retained in the skin from the NLC formulation compared to non-nanosized control formulations, with and without oleic acid. This demonstrated the potential of these lipid based nanosystems to act as suitable agents for the topical delivery of quercetin. Both SLN and NLC formulations were also found to have no genotoxic or cytotoxic effects at the concentrations evaluated.
Subject
(authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4219
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xx, 160 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Sonali Bose
Subject
(authority = ETD-LCSH)
Topic
Quercetin
Subject
(authority = ETD-LCSH)
Topic
Nanoparticles
Subject
(authority = ETD-LCSH)
Topic
Lipids--Research
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066641
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
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(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3765D5F
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Bose
GivenName
Sonali
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-09-09 20:41:39
AssociatedEntity
Name
Sonali Bose
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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