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Modeling and analysis of continuous powder blending

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TitleInfo
Title
Modeling and analysis of continuous powder blending
Name (type = personal)
NamePart (type = family)
Gao
NamePart (type = given)
Yijie
NamePart (type = date)
1985-
DisplayForm
Yijie Gao
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Ramachandra
NamePart (type = given)
Rohit
DisplayForm
Rohit Ramachandra
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Ierapetritou
NamePart (type = given)
Marianthi G
DisplayForm
Marianthi G Ierapetritou
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Muzzio
NamePart (type = given)
Fernando J
DisplayForm
Fernando J Muzzio
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Cuitino
NamePart (type = given)
Alberto
DisplayForm
Alberto Cuitino
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-10
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The main focus of our research is to investigate continuous powder blending. The unit operation of powder blending is widely used to reduce the heterogeneity degree of product mixture in the manufacture of catalysts, cement, food, metal parts, and many other industrial products. Currently in pharmaceutical industry, continuous powder blending has received more attention as an efficient alternative to the traditional batch blending of powders due to its ability in handling high-flux continuous tablet manufacturing. Numerous previous approaches have been performed focusing on investigating the applicability of continuous manufacturing system. However, the development of reliable industrial system is limited by the inaccuracy of mixing index, the complicated effects of operating conditions and the black-box characterization method, all of which result from the lack of a theoretical model that can quantitatively characterize the whole continuous powder mixing process. Therefore, the overall research objective of this work is to develop a general standard method for quantitative process design and control. In this context, three different specific aims are accomplished. We analyze and distinguish different heterogeneity sources in the continuous blending process and develop a general model of continuous blending. Fourier series is applied to characterize the axial blending component, and a periodic section model is developed to capture the cross-sectional blending component. Based on the modeling work, efficient design, control, and scale-up strategies applicable for practical blending of pharmaceutical powders are determined. The effectiveness of the methodology is demonstrated in particle blending simulations and experiments using industrial mixing apparatuses to check its applicability and robustness in pharmaceutical industrial use.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4154
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiii, 164 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Yijie Gao
Subject (authority = ETD-LCSH)
Topic
Powders--Mixing
Subject (authority = ETD-LCSH)
Topic
Manufacturing processes--Automation
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066741
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T38914N7
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Gao
GivenName
Yijie
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-06-20 09:54:30
AssociatedEntity
Name
Yijie Gao
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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