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Neuronal adaptive responses to oxygen deprivation
Descriptive
TitleInfo
Title
Neuronal adaptive responses to oxygen deprivation
SubTitle
alterations In glutamate receptor trafficking and mitochondrial dynamics
Name
(type = personal)
NamePart
(type = family)
Ghose
NamePart
(type = given)
Piya
NamePart
(type = date)
1981-
DisplayForm
Piya Ghose
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Driscoll
NamePart
(type = given)
Monica
DisplayForm
Monica Driscoll
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Rongo
NamePart
(type = given)
Christopher
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Christopher Rongo
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Firestein
NamePart
(type = given)
Bonnie
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Bonnie Firestein
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Barr
NamePart
(type = given)
Maureen
DisplayForm
Maureen Barr
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Singson
NamePart
(type = given)
Andrew
DisplayForm
Andrew Singson
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Subject
(authority = RUETD)
Topic
Neuroscience
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4208
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
xix, 255 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Piya Ghose
Abstract
(type = abstract)
Adaptability to changing environmental oxygen levels is important for the survival of aerobic organisms. Neurons in particular are vulnerable to oxygen deprivation (hypoxia), and hypoxia-induced degeneration is a hallmark of ischemic stroke, a leading cause of morbidity and disability. Ischemic stroke damages neurons through a combination of hypoxia-induced neuronal membrane depolarization, excess glutamate receptor activation, altered intracellular calcium homeostasis, and mitochondrial dysfunction. Neurons from different species or even from different brain regions of the same species have varying tolerances to oxygen deprivation, yet little is known about how neurons adapt to the stress of oxygen deprivation. Examining the causality of this differential resistance is particularly challenging in mammalian neurons given their inherent sensitivity to this stress. The soil nematode C. elegans serves as a hypoxia-adaptable model organism that can be used to examine how neurons handle oxygen deprivation. In the
dissertation work presented here, I have employed C. elegans to study the hypoxic regulation of two key cell biological components important for the progression of hypoxia–induced neuronal death: glutamate receptors and
mitochondria. In these studies, I report our identification of a novel variant of the hypoxia response pathway dedicated to the modulation of C. elegans glutamate receptor trafficking. In addition, I report that the dynamics of mitochondrial fission
and fusion are altered in response to oxygen deprivation in C. elegans neurons. I also present data suggesting that the canonical hypoxia response pathway regulates this dynamic response. These alterations in glutamate receptor trafficking and mitochondrial dynamics are accompanied by behavioral changes and possibly promote survival in response to oxygen deprivation. My findings indicate that neurons protect themselves by executing a complex and multilayered homeostatic response to reduced oxygen availability that
incorporates both transcriptional and posttranslational mechanisms.
dissertation work presented here, I have employed C. elegans to study the hypoxic regulation of two key cell biological components important for the progression of hypoxia–induced neuronal death: glutamate receptors and
mitochondria. In these studies, I report our identification of a novel variant of the hypoxia response pathway dedicated to the modulation of C. elegans glutamate receptor trafficking. In addition, I report that the dynamics of mitochondrial fission
and fusion are altered in response to oxygen deprivation in C. elegans neurons. I also present data suggesting that the canonical hypoxia response pathway regulates this dynamic response. These alterations in glutamate receptor trafficking and mitochondrial dynamics are accompanied by behavioral changes and possibly promote survival in response to oxygen deprivation. My findings indicate that neurons protect themselves by executing a complex and multilayered homeostatic response to reduced oxygen availability that
incorporates both transcriptional and posttranslational mechanisms.
Subject
(authority = ETD-LCSH)
Topic
Neurons
Subject
(authority = ETD-LCSH)
Topic
Oxygen consumption (Physiology)
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066744
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3VT1QNQ
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Ghose
GivenName
Piya
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-08-28 12:04:32
AssociatedEntity
Name
Piya Ghose
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2012-10-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2014-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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