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Consumption of sugary foods and drinks and risk of endometrial and ovarian cancers
Descriptive
TitleInfo
Title
Consumption of sugary foods and drinks and risk of endometrial and ovarian cancers
Name
(type = personal)
NamePart
(type = family)
King
NamePart
(type = given)
Melony G.
NamePart
(type = date)
1983-
DisplayForm
Melony King
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Bandera
NamePart
(type = given)
Elisa V
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Elisa V Bandera
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
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(type = family)
DEMISSIE
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KITAW
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KITAW DEMISSIE
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Lu
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(type = given)
Shou-En
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Shou-En Lu
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Olson
NamePart
(type = given)
Sara H
DisplayForm
Sara H Olson
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Endometrial and ovarian cancers are among the top ten cancers that occur in women in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, there is limited evidence on how sugar consumption affects risk of these cancers. Our review of the published literature on sugar consumption and endometrial and ovarian cancers yielded inconsistent results. Furthermore, we found that few studies considered effect modification by insulin-related risk factors [i.e. body mass index, waist-to-hip ratio (WHR), physical activity]. Using data from two related New Jersey population-based case-control studies, we evaluated endometrial and ovarian cancer risk in relation to sugary foods and beverages, and total and added sugar intakes, while considering effect modification by insulin-related factors. In our first study, women in the highest quartile of added sugar intake had significantly higher endometrial cancer risk (OR=1.84, 95% CI:1.16-2.92). Sugary drink intake moderately increased endometrial cancer risk with each unit increase (OR=1.61, 95% CI:1.09-2.40 per serving/1000 kcal). Among women with WHR >0.85, risk was significantly higher for the highest vs. lowest tertile of added sugar intakes (OR=2.50, 95% CI:1.38-4.52). The association with added sugar also became stronger when analyses were restricted to never users of hormone replacement therapy (OR: 2.03; 95% CI: 1.27-3.26 for highest vs. lowest tertile). For ovarian cancer, we did not find evidence of an association between consumption of sugary foods and beverages and risk. In conclusion, we performed a comprehensive assessment of sugar intake and endometrial and ovarian cancer risk, with consideration of insulin-modifiers. Endometrial cancer risk was adversely related to sugary drink and added sugar intakes, after adjusting for several major risk factors. Also, there was evidence that insulin-related risk factors, mainly central obesity, modified these relationships. However, there was little indication that sugar intake influenced ovarian cancer risk. Our study is the first to evaluate endometrial and ovarian cancer risk in relation to added sugar consumption from all food sources, while considering effect modification by several insulin-related factors. Given the high prevalence of intake of sugary foods and drinks in Western populations, additional research is warranted to confirm our findings on endometrial cancer and to further elucidate the role of sugar intake on ovarian cancer risk.
Subject
(authority = RUETD)
Topic
Public Health
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4306
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
viii, 90 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Melony G. King
Subject
(authority = ETD-LCSH)
Topic
Ovaries--Cancer--Nutritional aspects
Subject
(authority = ETD-LCSH)
Topic
Diet in disease--New Jersey
Subject
(authority = ETD-LCSH)
Topic
Endometrium--Cancer--Nutritional aspects
Subject
(authority = ETD-LCSH)
Topic
Food--Sugar content
Subject
(authority = ETD-LCSH)
Topic
Cancer in women
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066846
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3WQ02KV
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
King
GivenName
Melony
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-09-27 14:13:59
AssociatedEntity
Name
Melony King
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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744448
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