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Polymers for the sustained and localized release of anti-inflammatory and anti-cancer drugs
Descriptive
TitleInfo
Title
Polymers for the sustained and localized release of anti-inflammatory and anti-cancer drugs
Name
(type = personal)
NamePart
(type = family)
Memoli
NamePart
(type = given)
Kevin A.
NamePart
(type = date)
1959-
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kevin memoli
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Uhrich
NamePart
(type = given)
Kathryn E
DisplayForm
Kathryn E Uhrich
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Williams
NamePart
(type = given)
Lawrence J
DisplayForm
Lawrence J Williams
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Hultzsch
NamePart
(type = given)
Kai
DisplayForm
Kai Hultzsch
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
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2012
DateOther
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(type = degree)
2012-10
Place
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(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The practical utility of chemically incorporating drugs into polymers for the localized and sustained delivery of such drugs has been well established. Sustained release provides therapeutic concentrations of drug over a long time period, obviating the need for frequent dosing, leading to better patient compliance and mitigating the likelihood of overdosing. Localized delivery mitigates the severity of side effects associated with systemic administration and increases efficacy by increasing the effective dosage at the site of the pathology. In this thesis, these principles have been investigated for the delivery of anti-inflammatory and anti-cancer drugs. Amfenac, a non-steroidal anti-inflammatory drug (NSAID), in the form of its prodrug nepafenac, has been proven to be effective for the treatment of anterior uveitis (i.e. ocular inflammation) via topical administration of an aqueous suspension, but posterior uveitis is difficult to treat in this manner as drug penetration to the rear of the eye is inefficient and clearance is very rapid, limiting the practicality of administration by injection. The objective was to chemically incorporate amfenac into a biodegradable polymer that can be fabricated into microspheres suitable for injection into the rear of the eye for the sustained release of amfenac to treat posterior uveitis. This polymer consists of a poly(amide-imine) derived from an analog of nepafenac. Herein is described the polymer synthesis and the preparation and degradation of PolyAspirinTM microspheres incorporating sodium amfenac. Nutlin is a member of an anti-cancer drug family developed by Hoffmann-LaRoche, Inc. The objective of this project was to attach a nutlin analog to a biodegradable polymer backbone and fabricate the resulting polymer into wafers that could be surgically implanted to treat brain cancer. Described herein are efforts to incorporate a nutlin analog into a polymer backbone based on pyromellitic acid.
Subject
(authority = RUETD)
Topic
Chemistry and Chemical Biology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_4257
PhysicalDescription
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
x, [54] p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Kevin A. Memoli
Subject
(authority = ETD-LCSH)
Topic
Polymeric drug delivery systems
Subject
(authority = ETD-LCSH)
Topic
Drugs--Controlled release
Subject
(authority = ETD-LCSH)
Topic
Anti-inflammatory agents--Controlled release
Subject
(authority = ETD-LCSH)
Topic
Cancer--Treatment
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066913
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3930RZK
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
memoli
GivenName
kevin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-09-20 15:24:14
AssociatedEntity
Name
kevin memoli
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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