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Developing a multifunctional nanocomposite using albumin-encapsulated rare-earth doped nanoparticles for tumor targeting

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TitleInfo
Title
Developing a multifunctional nanocomposite using albumin-encapsulated rare-earth doped nanoparticles for tumor targeting
Name (type = personal)
NamePart (type = family)
Naczynski
NamePart (type = given)
Dominik Jan
NamePart (type = date)
1984-
DisplayForm
Dominik Naczynski
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Moghe
NamePart (type = given)
Prabhas V.
DisplayForm
Prabhas V. Moghe
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Roth
NamePart (type = given)
Charles M.
DisplayForm
Charles M. Roth
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Riman
NamePart (type = given)
Richard E.
DisplayForm
Richard E. Riman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Sinko
NamePart (type = given)
Patrick J.
DisplayForm
Patrick J. Sinko
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Chen
NamePart (type = given)
Suzie
DisplayForm
Suzie Chen
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-10
CopyrightDate (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Optically guided imaging of diseases and surgical procedures is challenged by the lack of photoluminescent probes that can be sensitively detected within living tissues and tracked in real-time. The use of visible light for the detection of conventional probes suffers from poor tissue penetration and non-specific fluorescence. Emerging probes excited using near infrared light (NIR) reduce undesired tissue absorbance, however light scattering resulting from the complex heterogeneity of biological tissues limits the penetration depth of light propagation. Optical probes that emit over a new window of electromagnetic radiation in the short wavelength infrared (SWIR) region can significantly improve in vivo imaging sensitivity compared to NIR. However, current SWIR-detectable probes lack the optical tunability and biocompatibility requisite for biological implantation in vivo. This doctoral dissertation is focused on investigating albumin-derived, biologically interactive nanoparticles as a platform system that can be designed with distinct multifunctional properties, particularly, SWIR imaging and the delivery of therapeutic cargo. The bulk of the thesis is focused on conceptualizing and developing a new class of SWIR-detectable nanomaterials for targeted imaging of cancerous tissues. Conventionally fabricated rare-earth doped nanoprobes (REs) are weakly bioavailable, lack functional surface groups for tissue targeting and exhibit potential cytotoxicity. A major research effort of this thesis was to develop albumin nanoshells around rare-earth nanoprobes for establishing highly biocompatible and biologically targetable RE nanocomposites with controlled sizes and pharmacodynamic behaviors. This study also produced the first evidence reported to date of multi-spectral, real-time SWIR imaging at anatomical resolution in vivo and demonstrated the prospects of REs for targeted molecular imaging. The albumin-encapsulated, inorganic-organic nanocomposite of REs showed enhanced SWIR signal intensity in diseased tissue through accumulation of REs at tumor sites and extended the in vivo retention of REs. Further modifications were made to the albumin coating to create a multifunctional nanoparticle with tumor-penetrating and therapeutic delivery properties for both imaging and drug delivery applications. The cumulative findings of this thesis lay the groundwork for the design of new biomedical probes and imaging methods that have the potential to significantly advance surveillance of a range of diseases with complex molecular etiologies, from cancers to heart disease.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4206
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
iii, 218 p. : ill.
Note (type = degree)
Ph. D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Dominik Jan Naczynski
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
Subject (authority = ETD-LCSH)
Topic
Cancer--Imaging
Subject (authority = ETD-LCSH)
Topic
Albumins
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066924
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T36972B1
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Naczynski
GivenName
Dominik
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-08-27 17:14:54
AssociatedEntity
Name
Dominik Naczynski
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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