Home
Resource
I. Prodrugs based on the sulfamate linkage II. Seleninic acids as biomimetic enzyme inhibitors
PDF
PDF format is widely accepted and good for printing.
Plug-in required
PDF-1(2.07 MB)
Citation & Export
View Usage Statistics
Staff View

Citation & Export
Hide

Simple citation

Sun, Zhexun. I. Prodrugs based on the sulfamate linkage II. Seleninic acids as biomimetic enzyme inhibitors. Retrieved from https://doi.org/doi:10.7282/T38P5Z8J

Export

Click here for information about Citation Management Tools at Rutgers.

Statistics
Hide

Description

TitleI. Prodrugs based on the sulfamate linkage II. Seleninic acids as biomimetic enzyme inhibitors
NameSun, Zhexun (author); Knapp, Spencer (chair); Williams, Lawence (internal member); Jimenez, Lesilie (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2012
Other Date2012-10 (degree)
SubjectChemistry and Chemical Biology, Prodrugs, Enzyme inhibitors
Extentx, 89 p. : ill.
DescriptionThe most important two features of a successful drug are the biochemical effects of active pharmaceutical ingredients and the efficacy of their delivery methods. Synthetic organic chemistry plays crucial roles in virtually both of these aspects for the design and the development of new drugs. Herein, in the first half part of the dissertation, a novel synthesis strategy of sulfamate esters is developed, which has been successfully applied into the synthesis of several tripartate pro-drugs with the purpose of improving the delivery efficiency of ethinyl estradiol. Their pharmaceutical effects are evaluated by both in vitro and in vivo studies as described. In the second half part, novel synthesis of several biomimetic enzyme inhibitors, including selenoxide, diselenide, seleninic acid, and various other organoselenium compounds is reported. Evaluation of these biomimetics will be elucidated in the future.
NoteM.S.
NoteIncludes bibliographical references
NoteIncludes vita
Noteby Zhexun Sun
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T38P5Z8J
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
Version 8.5.5
Rutgers University Libraries - Copyright ©2024