RUcore: Rutgers University Community Repository
Characterization of impulsive-like behavior produced by developmental deltamethrin exposure
Descriptive
TitleInfo
Title
Characterization of impulsive-like behavior produced by developmental deltamethrin exposure
SubTitle
role of dopaminergic dysfunction
Name
(type = personal)
NamePart
(type = family)
Taylor
NamePart
(type = given)
Michele Marie
NamePart
(type = date)
1970-
DisplayForm
Michele Taylor
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Richardson
NamePart
(type = given)
Jason
DisplayForm
Jason Richardson
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Reuhl
NamePart
(type = given)
Kenneth
DisplayForm
Kenneth Reuhl
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
White
NamePart
(type = given)
Lori
DisplayForm
Lori White
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Aleksunes
NamePart
(type = given)
Lauren
DisplayForm
Lauren Aleksunes
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Cory-Slectha
NamePart
(type = given)
Deborah
DisplayForm
Deborah Cory-Slectha
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Attention-deficit hyperactivity disorder (ADHD) is characterized by impulsivity, hyperactivity and attention deficits, all of which are thought to arise from catecholaminergic dysfunction. Recent studies suggest pesticide exposure may contribute to the incidence or severity of ADHD. Here, we provide evidence that pesticide exposure may be involved in the pathogenesis of the disorder. We hypothesized that developmental exposure of mice to deltamethrin (DM) would produce impulsive-like behavior through alterations in dopaminergic function. Implementing an operant behavioral paradigm, we demonstrated that DM causes impulsive-like behavior as evidenced by deficits in waiting behavior and the capacity to inhibit responding or to refrain from responding during delays in reinforcement that was ameliorated by treatment with the common ADHD therapeutic, methylphenidate (MPD). In correlation with these data, MPD was quantified in murine plasma and tissue via electron spray ionization/ion trap mass spectrometry. MPD was found at detectable levels in both matrices and remained so for at least 2 hrs, a time frame consistent with reversal by MPD of DM- induced behavioral alterations. To determine the contribution of dopamine receptor subtypes D1 and D2 on impulsive-like behavior, we utilized a fixed-interval (FI) schedule of reinforcement together with dopamine receptor antagonist treatment. Developmental DM produced a response pattern similar to that of children diagnosed with ADHD. Once baseline performance was established, D1- and D2-receptor antagonists SCH 23390 and eticlopride (ETI) were administered. Each returned some of DM-induced FI performance alterations to control levels, suggesting a role for both subtypes. To determine whether there is a relationship between receptor density alterations and consequent behavioral dysfunction following developmental DM exposure, we used quantitative autoradiography to determine the density of the D1- and D2-like dopamine receptors in the striatum (STR). We found changes in D1 but not D2-like dopamine receptor density and homogenate binding as a result of DM-exposure. Since there has been a dramatic increase in the amount of pyrethroid pesticides used recently and exposure of pregnant women to pyrethroids has been confirmed, it is important to determine the mechanism by which they affect the dopamine system and whether pyrethroid exposure might contribute to the pathogenesis of ADHD.
Subject
(authority = RUETD)
Topic
Toxicology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_1358
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiv, 153 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Michele Marie Taylor
Subject
(authority = ETD-LCSH)
Topic
Attention-deficit hyperactivity disorder--Etiology
Subject
(authority = ETD-LCSH)
Topic
Pesticides--Physiological effect
Subject
(authority = ETD-LCSH)
Topic
Impulse control disorders
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066997
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3DF6Q08
Genre
(authority = ExL-Esploro)
ETD doctoral
Back to the top
Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Taylor
GivenName
Michele
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-05-10 00:16:11
AssociatedEntity
Name
Michele Taylor
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top
Technical
FileSize
(UNIT = bytes)
1448448
OperatingSystem
(VERSION = 5.1)
windows xp
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
MimeType
(TYPE = container)
application/x-tar
FileSize
(UNIT = bytes)
1454080
Checksum
(METHOD = SHA1)
2c47c188e46531869d1c440ebc27a3f46bd6a467
Back to the top
Statistical Profile