Home
Resource
Novel perspectives in cancer chemoprevention via Nrf2 pathway
PDF
PDF format is widely accepted and good for printing.
Plug-in required
PDF-1(3.76 MB)
Citation & Export
View Usage Statistics
Staff View

Citation & Export
Hide

Simple citation

Wu, Tien-Yuan. Novel perspectives in cancer chemoprevention via Nrf2 pathway. Retrieved from https://doi.org/doi:10.7282/T37S7MJG

Export

Click here for information about Citation Management Tools at Rutgers.

Statistics
Hide

Description

TitleNovel perspectives in cancer chemoprevention via Nrf2 pathway
NameWu, Tien-Yuan (author); KONG, AH-NG (chair); Chen, Suzie (internal member); Suh, Nanjoo (internal member); Androulakis, Ioannis P. (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2012
Other Date2012-10 (degree)
SubjectPharmaceutical Science, Cancer--Chemoprevention, Phytochemicals, Pharmacogenomics
Extentxvi, 151 p. : ill.
DescriptionThe cancer chemoprevention is the strategy of blocking or slowing the onset of premalignant tumors and decreases the incidence of cancer with relatively nontoxic chemical substance. More importantly, Nrf2 and Nrf2-antioxidant response element (ARE) pathway plays a critical role in the cancer chemoprevention. Studies of the induction of Nrf2 and subsequent phase II detoxifying/antioxidant drug metabolism enzymes expression by phytochemicals in vivo or in vitro are considered as a major topic. This thesis will focus on the factors important in the regulation of Nrf2 and phase II xenobiotic metabolizing enzymes which are generally considered as antioxidant and detoxifying enzymes in cancer chemoprevention. Accumulating evidence from epidemiological studies indicates that chronic inflammation and oxidative stress play critical roles in neoplastic development. Our results show that tea Chrysanthemun zawadskii (CZ) and licorice Glycyrrhiza uralensis (LE) extracts exhibited potent anti-inflammatory activities by suppressing the mRNA and protein expression levels of pro-inflammatory biomarkers and the NF-kB luciferase activity. Both extracts also showed strong inhibitory effects against NF-kB-mediated inflammatory as well as strong activation of the Nrf2-ARE-antioxidative stress signaling pathways. Indole-3-carbinol (I3C) and its acid condensation product, 3,3’-diindolylmethane (DIM) were examined the chemopreventive effect and the molecular mechanism, particularly the anti-oxidative stress pathway regulated by Nrf2, in transgenic adenocarcinoma of mouse prostate (TRAMP) mice and TRAMP C1 cells. I3C and DIM significantly suppressed the incidence of palpable tumor (p<0.05) and reduced the genitourinary weight (p<0.05) and induced Nrf2 and related genes expression in TRAMP mice. DIM can also epigenetically modify the CpG methylation status of Nrf2 in vivo and in vitro, and enhanced expression of Nrf2 and Nrf2-mediated genes. Using dietary phytochemicals to modulate the genomic as well as epigenomic is thought to be plausible in cancer chemoprevention in the future.
NotePh.D.
NoteIncludes bibliographical references
NoteIncludes vita
Noteby Tien-Yuan Wu
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T37S7MJG
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
Version 8.5.5
Rutgers University Libraries - Copyright ©2024