DNA damaged bases are one of the reasons for a variety diseases, such as carcinogenesis, aging and cell death. uracil is a nucleobase that arises from cytosine deamination. N-Deprotonated uracil functions as a leaving group during the deamination process. Theoretically, in the SN2 reaction, leaving group ability tracks with pKa of the conjugate acid in the solution phase, that is, lower pKa is associated with better leaving group ability. In the gas phase, leaving group ability is better with higher acidity of the conjugate acid. The studies we did previously showed that although 3-methyluracil is as acidic as hydrochloric acid in the gas phase, the leaving group ability of chloride is better than deprotonated 3-methyluracil. The reason we propose this is that the electron delocalization in the transition state of SN2 reaction cannot be fully recognized as in acidity. Therefore, we designed substituted aniline and amine with leaving groups with or without the ability of electron delocalization and found that substituted amine with leaving groups that did not have the ability of electron delocalization tracked better with acidity than the one with the ability of electron delocalization. The result is consistent with our proposal. We also tested the Hammond postulate with the calculation results. Another focus of interest is N-heterocyclic singlet carbenes (NHCs), which are ligands of a variety of organometallic catalysts. Presumably the ligands are more effective if they are more basic, that is, with higher proton affinity. The protonated carbenes are also an important class of ionic liquids, known as green solvents with several advantages over traditional organic solvents. Strassner et al designed a new type of ionic liquid imidazolium salt with tunable para-aryl substituent, and we measured the acidity of these tunable aryl-alkyl ionic liquids (TAAILs). The proton-bound dimers of dimethyl imidazole and PCy3 are found to exhibit interesting reactivity. In addition to producing just protonated carbenes and protonated phosphine with collision induced dissociation (CID), the proton-bound dimers generate another ion of interest with m/z 295. We designed and synthesized the di-CD3 imidazole, and proved that the dimethyl system undergoes phosphine methylation during CID process.
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Chemistry and Chemical Biology
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Rutgers University Electronic Theses and Dissertations
Rutgers University. Graduate School - New Brunswick
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