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Investigation of arterial compliance and wave reflections as markers of hypertension
Descriptive
TitleInfo
Title
Investigation of arterial compliance and wave reflections as markers of hypertension
Name
(type = personal)
NamePart
(type = family)
Bhavsar
NamePart
(type = given)
Nihir
NamePart
(type = date)
1986-
DisplayForm
Nihir Bhavsar
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Li
NamePart
(type = given)
John K-J.
DisplayForm
John K-J. Li
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Shoane
NamePart
(type = given)
George K
DisplayForm
George K Shoane
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Drzewiecki
NamePart
(type = given)
Gary M
DisplayForm
Gary M Drzewiecki
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Hypertension is the primary risk factor for many forms of cardiovascular diseases, which are the leading cause of death in the developed world. Hypertension and myocardial ischemia are also main contributors to stroke, which results in serious and long-term disability. Early detection, monitoring, and treatment of hypertension and myocardial ischemia are thus important in the delay or prevention of morbidity and mortality from cardiovascular diseases. This thesis investigates new hemodynamic markers that are critical in the diagnosis and assessment of the severity of hypertension and myocardial ischemia. Experimental data was obtained from anesthetized mongrel dogs for control, hypertension, vasodilation, and myocardial ischemia. Simultaneously recorded aortic pressure and aortic flow waveforms were digitized for calculations of hemodynamic parameters. Model-based linear and nonlinear arterial compliances, the compliance- pressure relationship, and different augmentation indices for assessing the effects of wave reflections were computed and evaluated as markers of hypertension. Analysis of the modified three-element nonlinear Windkessel model or the Li- Model revealed a nonlinear blood pressure and arterial compliance relationship and indicated that this model better predicts the blood pressure waveforms during hypertension and vasodilation. The compliance-pressure loops constructed for a single beat demonstrated reduced compliance during hypertension and increased compliance during vasodilation and ischemia. Analysis of the augmentation index revealed that blood pressure is indeed augmented in systole during hypertension and reduced during vasodilation and ischemia. The newly presented methods for augmentation index calculation are also shown to be better indicators of wave reflection effects in hypertension. Thus, these new nonlinear compliance and augmentation indices may be useful markers in the diagnosis and treatment of hypertension.
Subject
(authority = RUETD)
Topic
Biomedical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4322
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
ix, 80 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Nihir Bhavsar
Subject
(authority = ETD-LCSH)
Topic
Hypertension--Diagnosis
Subject
(authority = ETD-LCSH)
Topic
Hemodynamics
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066636
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T39022JN
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Bhavsar
GivenName
Nihir
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-09-28 13:57:47
AssociatedEntity
Name
Nihir Bhavsar
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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3697152
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windows xp
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ETD
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application/pdf
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3706880
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