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Synthesis and characterization of collagen methacrylamide sponges for use as a biological scaffold

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TitleInfo
Title
Synthesis and characterization of collagen methacrylamide sponges for use as a biological scaffold
Name (type = personal)
NamePart (type = family)
Branch
NamePart (type = given)
Jonathan Richard
DisplayForm
Jonathan Branch
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shreiber
NamePart (type = given)
David
DisplayForm
David Shreiber
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Berthiaume
NamePart (type = given)
Francois
DisplayForm
Francois Berthiaume
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Dunn
NamePart (type = given)
Michael
DisplayForm
Michael Dunn
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-10
CopyrightDate (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The goal of this thesis was to develop collagen methacrylamide (CMA) into a functional biological scaffold by enhancing its physical strength. CMA is a biocompatible, functionalized type I collagen moiety whose physical strength can be modulated by UV light exposure. Commercially-available, collagen-based biological devices comprised of decellularized ECM possess excellent mechanical properties, but are limited in their amenability to physical and chemical patterning. Scaffolds manufactured from purified collagens are not suitable for most biomedical applications because of their limited physical strength. In the first study, collagen methacrylamide was processed into sponges by lyophilization. Subsequently, the material was characterized through rheometry and found to be weaker than its corresponding hydrogel. A second study evaluated increasing the concentration of the material to increase its strength. In a third study, EDC crosslinking was employed as an additional method to increase the strength of CMA. Both studies demonstrated an increase in the tensile strength and elastic modulus of CMA sponges. However, further increases in strength will be necessary in order for this device to be feasible as a biological scaffold. Nevertheless, the potential exists for CMA sponges, containing gradients of stiffness or peptide-patterning, to be developed into a superior material for numerous tissue engineering applications.
Subject (authority = RUETD)
Topic
Biomedical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4298
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiii, 106 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Jonathan Richard Branch
Subject (authority = ETD-LCSH)
Topic
Collagen
Subject (authority = ETD-LCSH)
Topic
Biology--Research
Subject (authority = ETD-LCSH)
Topic
Tissue scaffolds
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066644
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3DR2T8P
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Branch
GivenName
Jonathan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-09-26 19:36:33
AssociatedEntity
Name
Jonathan Branch
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

FileSize (UNIT = bytes)
4162560
OperatingSystem (VERSION = 5.1)
windows xp
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ETD
MimeType (TYPE = file)
application/pdf
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application/x-tar
FileSize (UNIT = bytes)
4167680
Checksum (METHOD = SHA1)
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