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Accessing erythronolide structure space

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TitleInfo
Title
Accessing erythronolide structure space
SubTitle
new reactions and applications
Name (type = personal)
NamePart (type = family)
Liu
NamePart (type = given)
Kai
NamePart (type = date)
1985-
DisplayForm
Kai Liu
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Williams
NamePart (type = given)
Lawrence J
DisplayForm
Lawrence J Williams
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Jones
NamePart (type = given)
Roger A
DisplayForm
Roger A Jones
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Seidel
NamePart (type = given)
Daniel
DisplayForm
Daniel Seidel
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Hu
NamePart (type = given)
Longqin
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Longqin Hu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-10
CopyrightDate (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
An integrated routing strategy approach towards the synthesis of novel erythronolides is discussed in this dissertation. A macrocyclic bis[allene] compound was made as a synthetic scaffold. To date, more than 30 erythronolide derivatives have been made from this intermediate within 3 steps or less. This approach represents by far the most efficient and economic route for the access of erythronolide structure space. Many reactions were utilized in the modification of these 14-membered macrolides, including bromination, chelation and non-chelation controlled reductions and benzylic migration, elimination, etc. More importantly, novel allene oxidation conditions such as allene epoxidation, spirodiepoxidation, and osmylation, transformations developed by our group, were applied in the synthesis of diverse erythronolides and were central to our strategy. New reactions, including new procedures of allene dihydroxylation and allene osmylation-electrophile addition, are also discussed.
Subject (authority = RUETD)
Topic
Chemistry and Chemical Biology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4237
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiii, 285 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Kai Liu
Subject (authority = ETD-LCSH)
Topic
Organic compounds--Synthesis
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066895
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3MC8XRJ
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Liu
GivenName
Kai
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-09-14 10:28:40
AssociatedEntity
Name
Kai Liu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2013-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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