RUcore: Rutgers University Community Repository
Investigation of the behavioral processes and neurobiological substrates involved in the motivation for voluntary wheel running in the rat
Descriptive
TitleInfo
Title
Investigation of the behavioral processes and neurobiological substrates involved in the motivation for voluntary wheel running in the rat
Name
(type = personal)
NamePart
(type = family)
Basso
NamePart
(type = given)
Julia Colette
NamePart
(type = date)
1982-
DisplayForm
Julia Basso
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Delgado
NamePart
(type = given)
Mauricio R
DisplayForm
Mauricio R Delgado
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Morrell
NamePart
(type = given)
Joan I
DisplayForm
Joan I Morrell
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Abercrombie
NamePart
(type = given)
Elizabeth D
DisplayForm
Elizabeth D Abercrombie
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Pare
NamePart
(type = given)
Denis
DisplayForm
Denis Pare
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Zaborszky
NamePart
(type = given)
Laszlo
DisplayForm
Laszlo Zaborszky
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Eikelboom
NamePart
(type = given)
Roelof
DisplayForm
Roelof Eikelboom
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
Genre
(authority = ExL-Esploro)
ETD doctoral
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-01
CopyrightDate
(encoding = marc);
(point = start);
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Rats engage with voluntary running wheels spontaneously and come to run tremendous, stable distances over the first 3 weeks of wheel exposure, with males and females showing significant differences in this behavior. Though voluntary running has been utilized extensively to study its effects on the body and brain, less has been done to examine the behavior itself, and specifically lacking are studies that focus on the motivation for the behavior and any gender differences within. Here, I investigate, in a comprehensive, quantitatively comparable manner, details of voluntary wheel running and variables that affect it in both male and female Sprague Dawley rats. Using both unconditioned and conditioned techniques, I explore my primary hypothesis that voluntary wheel running is a motivated behavior with positive incentive salience, with a focus on the motivation for this behavior during both the acquisition and habitual phases of running. I then utilize these behavioral techniques to explore the involvement of discrete brain regions in the motivation for voluntary wheel running. Results from this work support the hypothesis that voluntary wheel running is a motivated behavior with positive incentive salience. The data reveal that females acquire the behavior more quickly and during habitual phases of running, run significantly farther distances at faster rates. Additionally, I show using high-performance liquid chromatography that participating in voluntary wheel running throughout life alters neurotransmitter content in brain areas including the caudate putamen, ventral tegmental area, medial prefrontal cortex (mPFC) and medial preoptic area, and that engaging in this motivated behavior throughout life alters both the neurochemical and behavioral responsiveness to an acute dose of cocaine. Though males and females show an equally robust conditioned place preference for the total experience of running during the acquisition phase, the reinstatement of running after a period of forced wheel abstinence is greater for females than males, with males showing a stronger preference for the aftereffects of wheel running. Finally, I reveal for the first time that the prelimbic mPFC and nucleus accumbens core may be necessary for the motivation for voluntary wheel running.
Subject
(authority = RUETD)
Topic
Neuroscience
Subject
(authority = ETD-LCSH)
Topic
Rats as laboratory animals
Subject
(authority = ETD-LCSH)
Topic
Rats--Behavior
Subject
(authority = ETD-LCSH)
Topic
Rats--Locomotion
Subject
(authority = ETD-LCSH)
Topic
Rats--Psychology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Identifier
ETD_4501
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000067344
Identifier
(type = doi)
doi:10.7282/T3RR1X02
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 262 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Julia Colette Basso
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Back to the top
Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Basso
GivenName
Julia
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-01-08 12:38:47
AssociatedEntity
Name
Julia Basso
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top
Technical
RULTechMD
(ID = TECHNICAL1)
FileSize
(UNIT = bytes)
4085248
OperatingSystem
(VERSION = 5.1)
windows xp
ContentModel
ETD
Back to the top
Statistical Profile