DescriptionStudies have shown depression to affect up to 50% of individuals diagnosed with Parkinson’s disease (PD) and to have a negative impact on the progression of the illness. However, there is a dearth of research on psychosocial interventions for the treatment of depression in this population. To date, the utility of interpersonal psychotherapy (IPT), an evidence-based treatment for depression with demonstrated effectiveness in medical populations, has not been examined for this population. This case series was conducted to examine the feasibility and effectiveness of interpersonal psychotherapy (IPT) for depression in individuals with Parkinson’s disease (PD). Three PD patients with Major Depressive Disorder or Dysthymia participated in the study along with a caregiver. Patients received 6 to 15 sessions of IPT primarily focused on resolving the interpersonal problem area of role transition. Caregivers attended 1 to 2 sessions which provided psychoeducation and garnered necessary supports to help patients accomplish their treatment goals. Two of the patients experienced improvement in depressive symptoms, particularly in mood, interest and motivation in activities, with gains maintained at 1-month follow-up. There was some evidence of reductions in caregiver burden as a result of the intervention, though no significant change in caregiver depressive symptoms was noted. Results of this case series suggest that IPT may be a feasible and effective option for the treatment of PD depression. Larger, controlled trials are needed to replicate these results and to further evaluate the efficacy of this intervention.