Staff View
Basal forebrain cholinergic system

Descriptive

TitleInfo
Title
Basal forebrain cholinergic system
SubTitle
studies on intrinsic physiology and connectivity
Name (type = personal)
NamePart (type = family)
Ünal
NamePart (type = given)
Çağri Temuçin
DisplayForm
Cagri Unal
Role
RoleTerm (authority = RULIB)
author
NamePart (type = date)
1982-
Name (type = personal)
NamePart (type = family)
Golowasch
NamePart (type = given)
Jorge
DisplayForm
Jorge Golowasch
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Zaborszky
NamePart (type = given)
Laszlo
DisplayForm
Laszlo Zaborszky
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Koos
NamePart (type = given)
Tibor
DisplayForm
Tibor Koos
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Tepper
NamePart (type = given)
James
DisplayForm
James Tepper
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Nusser
NamePart (type = given)
Zoltan
DisplayForm
Zoltan Nusser
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-01
CopyrightDate (encoding = marc); (point = start); (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The term basal forebrain (BF) refers to a collection of nuclei found in the ventromedial aspects of the mammalian forebrain. The cholinergic corticopetal neurons in these nuclei received particular attention due to the intricate involvement of acetylcholine in cardinal cognitive functions. These neurons are referred to as the basal forebrain cholinergic (BFc) neurons and constitute the BFc system. This thesis asks three questions regarding the BFc system. The first question (Aim 1) pertains to the electrophysiological properties of its constituent neurons. Second question (Aim 2) deals with their interactions. The final question (Aim 3) is aimed at answering how these neurons modulate cellular properties in target neurons, considering the regular-spiking (RS) basolateral amygdala (BLA) neurons as a model system. To answer these questions, patch-clamp recordings in acute brain slices obtained from transgenic mice were done. The cholinergic effects on BFc neurons themselves and RS-BLA neurons were studied via optogenetically stimulating BFc neurons. Aim 1 revealed that BFc neurons can be differentiated into two electrophysiologically identifiable subtypes: early and late firing neurons. Early firing neurons (70%) are more excitable, show prominent spike frequency adaptation and are more susceptible to depolarization blockade, a phenomenon characterized by complete silencing of the neuron following an initial discharge of action potentials. Late firing neurons (30%), albeit being less excitable, could maintain a tonic discharge at low frequencies. In Aim 2, the inhibitory nature of BFc interactions were revealed using different approaches of slice electrophysiology that include the application of cholinergic agonists/antagonists, paired whole-cell recordings, and optogenetic activation of a subset of BFc neurons while recording the postsynaptic responses in others. The mechanisms and potential functional implications of these inhibitory actions are discussed in detail later. Experiments in Aim 3 were concerned with the effects of endogeneously released acetylcholine on RS-BLA neurons. The results reveal that cholinergic action depends on the recent history of RS-BLA neurons: It is excitatory following high frequency prior spiking while muscarinic inhibition dominates during lower firing frequencies. These results might point out to a thresholding function of acetylcholine in vivo.
Subject (authority = RUETD)
Topic
Behavioral and Neural Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4483
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xviii, 185 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Çağri Temuçin Ünal
Subject (authority = ETD-LCSH)
Topic
Prosencephalon--Physiology
Subject (authority = ETD-LCSH)
Topic
Neural transmission
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000067624
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3D79945
Genre (authority = ExL-Esploro)
ETD doctoral
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Unal
GivenName
Cagri
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-01-08 14:03:27
AssociatedEntity
Name
Cagri Unal
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
Back to the top
Version 8.4.8
Rutgers University Libraries - Copyright ©2022