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Chemical characterization of Sorghum bicolor leaf with antisickling activity

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TitleInfo
Title
Chemical characterization of Sorghum bicolor leaf with antisickling activity
Name (type = personal)
NamePart (type = family)
Gustafson
NamePart (type = given)
Kelsey
NamePart (type = date)
1984-
DisplayForm
Kelsey Gustafson
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Simon
NamePart (type = given)
James E
DisplayForm
James E Simon
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Wu
NamePart (type = given)
Qing-Li
DisplayForm
Qing-Li Wu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
LaVoie
NamePart (type = given)
Edmond J
DisplayForm
Edmond J LaVoie
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Sorghum bicolor is an important cereal and a staple crop in Africa, where it has been used traditionally by healers for the treatment of anemia and other health conditions. Interest in the plant typically focuses on the grain, but the leaves have recently been used in combination with three additional plants in the phytomedicine Nicosan, approved in Nigeria for the treatment of sickle cell disease. The ingredients of Nicosan were later found to be reducible to S. bicolor leaf and this new formula is currently under investigation for potential use in the treatment of sickle cell disease in the United States. In this research, both the raw botanical and the active botanical extract of S. bicolor leaf were chemically characterized as a first step in the standardization of a phytomedicine using a combination of various chromatographic and spectrometric techniques, including normal pressure chromatography, LC/UV/MS, and NMR methods. For standardization of the botanical materials, the characterized major compounds were quantitated using LC/UV/MS methods developed. In order to evaluate the safety of the phytomedicine, an analytical method for determination of the toxic cyanogenic glycoside dhurrin was also developed and validated. The results showed that the raw botanical contains high levels of dhurrin, but complete degradation of dhurrin occurred during the extraction process of the phytomedicine. To ensure the absence of cyanide, the breakdown product of dhurrin, cyanide content was analyzed using inorganic anion derivatization and GC/MS. The purpose of this investigation was to characterize a promising phytomedicine, which may provide relief to the debilitating pain suffered by patients with sickle cell disease.
Subject (authority = RUETD)
Topic
Medicinal Chemistry
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4443
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xi, 95 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Kelsey Gustafson
Subject (authority = ETD-LCSH)
Topic
Sorghum--Therapeutic use--Testing
Subject (authority = ETD-LCSH)
Topic
Sickle cell anemia--Treatment
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000067772
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T33J3BNB
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Gustafson
GivenName
Kelsey
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact)
2012-12-20 18:40:01
AssociatedEntity
Name
Kelsey Gustafson
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact)
2014-04-19
DateTime (encoding = w3cdtf); (point = end); (qualifier = exact)
2015-04-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after April 30, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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