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The cumulative risk of pharmaceuticals in New Jersey surface water to human health

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TitleInfo
Title
The cumulative risk of pharmaceuticals in New Jersey surface water to human health
Name (type = personal)
NamePart (type = family)
Roden
NamePart (type = given)
Nicholas Michael
DisplayForm
Nicholas Roden
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Robson
NamePart (type = given)
Mark G
DisplayForm
Mark G Robson
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
DiFerdinando, Jr.
NamePart (type = given)
George T
DisplayForm
George T DiFerdinando, Jr.
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Hong
NamePart (type = given)
Jun-Yan
DisplayForm
Jun-Yan Hong
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Sargent
NamePart (type = given)
Edward V
DisplayForm
Edward V Sargent
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Edward J. Bloustein School of Planning and Pub. Policy
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
Genre (authority = ExL-Esploro)
ETD doctoral
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract
Surface water in New Jersey is used to supply many residential drinking water facilities. In the surface water, there are contaminants from industrial and residential sources, one set of these contaminants being pharmaceuticals. This research looks at the concentrations of 18 pharmaceuticals in 30 locations in New Jersey, their acceptable daily exposures, and potential drug-drug interactions. The surface water sampling and analytical concentration determination was done by United States Geological survey (USGS) personnel according to their protocols and analyzed in a USGS laboratory. Acceptable daily exposures (ADE) for human health were set for each pharmaceutical in the study. Each pair of pharmaceuticals was researched for known adverse health interactions and their potential impact on human health was quantified. This interaction factor ranged from 0.4 times to 5.0 times the adverse effect, as measured in some cases by plasma levels in man. These factors were brought together using a cumulative hazard index risk assessment calculation to assess the overall risk of pharmaceuticals in surface water to human health. The cumulative risk was assessed for each of the 30 sample locations, and none reached the level of human health concern. When including the potential from drug-drug interactions in the assessment, the risk did increase but not an appreciable amount. The Hazard Index (HI) for the sample locations ranged from <0.00001 to 0.01 with the drug-drug interaction (DDI) only adding less than 1.2 times increase to the overall risk. When the simulation of these mixtures was extended to an extreme for drug-drug interactions, 7 times a noticeable increase in the calculated risk was seen, but in no cases did the risk in any of the sample locations reach a level of concern.
Subject (authority = RUETD)
Topic
Public Health
Subject (authority = ETD-LCSH)
Topic
Drinking water--Drug content--New Jersey
Subject (authority = ETD-LCSH)
Topic
Drinking water--Contamination--New Jersey
Subject (authority = ETD-LCSH)
Topic
Groundwater--Health aspects--New Jersey
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Bloustein Grad. School of Planning and Pub. Policy ETD Collection
Identifier (type = local)
rucore10003400001
Identifier
ETD_4435
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10003400001.ETD.000067702
Identifier (type = doi)
doi:10.7282/T3C24V3D
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 136 p. : ill.
Note (type = degree)
Dr.P.H.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Nicholas Michael Roden
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Roden
GivenName
Nicholas
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-12-18 23:11:14
AssociatedEntity
Name
Nicholas Roden
Role
Copyright holder
Affiliation
Rutgers University. Edward J. Bloustein School of Planning and Pub. Policy
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2013-08-02
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after August 2nd, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
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