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Effects of acute microinjections of thyroid hormone to the median preoptic nucleus of adult male rats on total sleep, loco-motor activity, and core body temperature
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Giannopoulos, Phillip. Effects of acute microinjections of thyroid hormone to the median preoptic nucleus of adult male rats on total sleep, loco-motor activity, and core body temperature. Retrieved from https://doi.org/doi:10.7282/T34Q7SMT

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TitleEffects of acute microinjections of thyroid hormone to the median preoptic nucleus of adult male rats on total sleep, loco-motor activity, and core body temperature
NameGiannopoulos, Phillip (author); Martin, Joseph V (chair); McIlroy, Patrick J (internal member); Saidel, William (internal member); Rutgers University; Camden Graduate School
Date Created2013
Other Date2013-05 (degree)
SubjectBiology, Thyroid gland--Diseases, Sleep disorders, Thyroid hormones
Extentvi, 49 p. : ill.
DescriptionOne clinical effect of dysthyroidism is often the disruption of normal sleep. The hypothalamus, more specifically the Median Preoptic Nucleus (MePO) contains highly restricted neuroanatomical clusters of sleep-active neurons. These neurons express GABAA receptors, which have previously been implicated in the onset and maintenance of sleep. T3 has been shown to inhibit the actions of benzodiazepines in electrophysiological experiments. The current experiment served to investigate possible non-genomic action of T3 microinjections to the MePO on sleep behavior over a series of 48-hour intervals, comprised of one 24-hour control and one 24-hour experimental interval. Injections to the MePO, of varying doses of T3 caused significantly different response effects on REM, non-REM, core-body temperature, and locomotor activity. The date indicated that T3 at 1 µg and 3 µg T3 injections caused a significant decrease in Total Sleep (TS) (P<0.0001 and P< 0.0001 respectively). T3 yielded a significant decrease in non-REM sleep (NREMS) for the doses of 1 µg, and 3 µg injections of T3 (P <0.0001 and P<0.0001 respectively along with an increase in REM sleep (REMS) in doses of 1 µg, and 3 µg T3 injections (P<0.03 and P<0.0001 respectively) within 24 hours of injection. These effects may be due to possible neurotransmitter or neurosteroid-like properties of T3 in the brain, or they may be from inhibitory protein phosphorylation effects found in previous experiments. Since the effects of T3 were demonstrated after acute injections, the data is consistent with possible non-genomic actions of thyroid hormones in the adult brain.
NoteM.S.
NoteIncludes bibliographical references
Noteby Phillip Giannopoulos
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T34Q7SMT
Languageeng
CollectionCamden Graduate School Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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