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Effects of acute microinjections of thyroid hormone to the median preoptic nucleus of adult male rats on total sleep, loco-motor activity, and core body temperature
Descriptive
TitleInfo
Title
Effects of acute microinjections of thyroid hormone to the median preoptic nucleus of adult male rats on total sleep, loco-motor activity, and core body temperature
Name
(type = personal)
NamePart
(type = family)
Giannopoulos
NamePart
(type = given)
Phillip
DisplayForm
Phillip Giannopoulos
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Martin
NamePart
(type = given)
Joseph V
DisplayForm
Joseph V Martin
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
McIlroy
NamePart
(type = given)
Patrick J
DisplayForm
Patrick J McIlroy
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Saidel
NamePart
(type = given)
William
DisplayForm
William Saidel
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Camden Graduate School
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
One clinical effect of dysthyroidism is often the disruption of normal sleep. The hypothalamus, more specifically the Median Preoptic Nucleus (MePO) contains highly restricted neuroanatomical clusters of sleep-active neurons. These neurons express GABAA receptors, which have previously been implicated in the onset and maintenance of sleep. T3 has been shown to inhibit the actions of benzodiazepines in electrophysiological experiments. The current experiment served to investigate possible non-genomic action of T3 microinjections to the MePO on sleep behavior over a series of 48-hour intervals, comprised of one 24-hour control and one 24-hour experimental interval. Injections to the MePO, of varying doses of T3 caused significantly different response effects on REM, non-REM, core-body temperature, and locomotor activity. The date indicated that T3 at 1 µg and 3 µg T3 injections caused a significant decrease in Total Sleep (TS) (P<0.0001 and P< 0.0001 respectively). T3 yielded a significant decrease in non-REM sleep (NREMS) for the doses of 1 µg, and 3 µg injections of T3 (P <0.0001 and P<0.0001 respectively along with an increase in REM sleep (REMS) in doses of 1 µg, and 3 µg T3 injections (P<0.03 and P<0.0001 respectively) within 24 hours of injection. These effects may be due to possible neurotransmitter or neurosteroid-like properties of T3 in the brain, or they may be from inhibitory protein phosphorylation effects found in previous experiments. Since the effects of T3 were demonstrated after acute injections, the data is consistent with possible non-genomic actions of thyroid hormones in the adult brain.
Subject
(authority = RUETD)
Topic
Biology
Subject
(authority = ETD-LCSH)
Topic
Thyroid gland--Diseases
Subject
(authority = ETD-LCSH)
Topic
Sleep disorders
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4850
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
Supplementary File: Abstract of thesis
Extent
vi, 49 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Phillip Giannopoulos
Subject
(authority = ETD-LCSH)
Topic
Thyroid hormones
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10005600001.ETD.000068570
RelatedItem
(type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier
(type = local)
rucore10005600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T34Q7SMT
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Giannopoulos
GivenName
Phillip
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-05-11 20:01:16
AssociatedEntity
Name
Phillip Giannopoulos
Role
Copyright holder
Affiliation
Rutgers University. Camden Graduate School
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
RULTechMD
(ID = TECHNICAL2)
ContentModel
ETD
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