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Predicting genetic interactions in the human genome
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Kawash, Joseph. Predicting genetic interactions in the human genome. Retrieved from https://doi.org/doi:10.7282/T3J101S4

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TitlePredicting genetic interactions in the human genome
NameKawash, Joseph (author); Grigoriev, Andrey (chair); Shain, Daniel (internal member); Nam, Jongmin (internal member); Rutgers University; Camden Graduate School
Date Created2013
Other Date2013-05 (degree)
SubjectComputational and Integrative Biology, Human genome, Human gene mapping, Genetic markers, Mammals--Cytology
Extentvii, 25 p. : ill.
DescriptionGenetic interaction and synthetic lethality are important tools that can be utilized to study the organization of a species genome. However genetic interaction information for mammalian and in particular human genomes is lacking when compared to other model organisms. This lack of information may be attributed to the difficulty and unreliability that seems to persist in acquiring information on genetic interactions from human cell lines. One method of resolving this problem is to use conserved genetic interactions identified in model organisms that can be extrapolated into the context of the mammalian genome. In this study, a survey is performed of genetic interaction networks from such model organisms including Saccharomyces cerevisiae, Drosophila melanogaster, and Caenorhabditis elegans to test the ability of predicting genetic interactions in mammalian genomes. Additional information supporting genetic interactions, from protein interaction datasets as well as human homologs, is used to reinforce the confidence in found potential interacting gene pairs. Using orthologous human gene identifiers, networks are overlaid in order to identify potentially conserved interactions for the purpose of identifying interacting genetic pairs in the mammalian genome. The common interactors are scored based on the model organism from which they were identified as well as their prevalence across different networks and supplemented through identification of homologous genes and human protein interactions. We find that there exist interacting gene pairs that are conserved between model organisms as well as human protein interactions. These interactions are verified using experimental information available from the literature to validate a subset of these findings.
NoteM.S.
NoteIncludes bibliographical references
Noteby Joseph Kawash
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3J101S4
Languageeng
CollectionCamden Graduate School Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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