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Oscillatory patterns along the entire septo-temporal axis of the hippocampus in behaving rats

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Title
Oscillatory patterns along the entire septo-temporal axis of the hippocampus in behaving rats
Name (type = personal)
NamePart (type = family)
Patel
NamePart (type = given)
Jagdish
NamePart (type = date)
1977-
DisplayForm
Jagdish Patel
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Pare
NamePart (type = given)
Denis
DisplayForm
Denis Pare
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Zaborszky
NamePart (type = given)
Lazlo
DisplayForm
Lazlo Zaborszky
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Nadim
NamePart (type = given)
Farzan
DisplayForm
Farzan Nadim
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Buzsaki
NamePart (type = given)
Gyorgy
DisplayForm
Gyorgy Buzsaki
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Fenton
NamePart (type = given)
Andre
DisplayForm
Andre Fenton
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The hippocampus exhibits two major modes of activity: Theta oscillations during the “online” active behavior and sharp-wave associated ripples during the “offline” inactive state. The rodent hippocampus is a complex C- shaped structure with a longitudinal axis (LA) of approximately 10mm. While theta and ripples oscillations have been extensively studied over the last 4 decades with strong evidence of their role in hippocampal memory functions, the organization of these oscillatory patterns along the LA has never been studied before. This lacuna is striking because there are genomic, anatomic, cellular, synaptic, and functional differences along its LA. My dissertation investigated the organization of theta (5-10Hz) and sharp wave associated ripple (140 -200Hz) oscillations along the entire LA of the hippocampus in behaving rats. Using multiple drives I simultaneously recorded local field potentials and single unit activity from multiple locations along the LA. The first study examined traveling theta waves. While the frequency of theta oscillations remained similar, theta amplitude and coherence between recording sites decreased from the dorsal to the ventral hippocampus. Theta phase shifted monotonically along the LA, reaching a maximum of 180o. While the majority of single units were phase-locked to the local field at all dorso-ventral segments, approximately 25% of single units from the ventral segment were phase locked to the dorsal hippocampal theta. Ventral hippocampal theta was weakly correlated with the locomotion velocity and varied independently of dorsal hippocampal theta. Thus, theta oscillations can temporally integrate or segregate neocortical representations along the LA of the hippocampus. The second study examined the local generation and spread of ripples. Qualitatively similar ripples occurred at all levels of the LA and propagated in both directions: septally or temporally, with an average speed of 0.35m/sec. While ripples propagated smoothly in the septal 2/3rd of the hippocampal tissue, ripples in the ventral segment remained isolated. These findings suggest that the septal hippocampus can use ripples to combine the information before transferring integrated signals to downstream targets. However, because ripples occur at different times in the ventral and dorsal segments, they broadcast independent information to their non-overlapping cortical and subcortical targets.
Subject (authority = RUETD)
Topic
Behavioral and Neural Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4774
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
x, 116 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Jagdish Patel
Subject (authority = ETD-LCSH)
Topic
Hippocampus (Brain)
Subject (authority = ETD-LCSH)
Topic
Oscillating chemical reactions
Subject (authority = ETD-LCSH)
Topic
Brain stimulation
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000068760
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3X065PS
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Patel
GivenName
Jagdish
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-04-30 12:36:32
AssociatedEntity
Name
Jagdish Patel
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-05-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2013-11-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after November 30th, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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