Staff View
Effects of De Novo protein synthesis on cell spreading, formation of cell-cell contacts, and co-localization of proteins at cell contacts in IAR-2 cells

Descriptive

TitleInfo
Title
Effects of De Novo protein synthesis on cell spreading, formation of cell-cell contacts, and co-localization of proteins at cell contacts in IAR-2 cells
Name (type = personal)
NamePart (type = family)
Sung
NamePart (type = given)
Linda
NamePart (type = date)
1987-
DisplayForm
Linda Sung
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Rodriguez
NamePart (type = given)
Alex J
DisplayForm
Alex J Rodriguez
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Cervantes-Cervantes
NamePart (type = given)
Miguel
DisplayForm
Miguel Cervantes-Cervantes
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Gao
NamePart (type = given)
Nan
DisplayForm
Nan Gao
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Rat epithelial cells were treated with translational inhibitors in order to study their effect on cell spreading, the cell’s ability to form lasting cell-cell contacts, and protein co-localization at cell contacts. When cells were treated with translation inhibitors they were found to have similar cell lengths as wild-type, untreated cells up to the 3 hour time point. After 3 hours the translational-inhibitor-treated cells were found to decrease in size while the untreated cells continued to grow. The co-localization of E-cadherin and actin were studied at cell contacts between two cells and it was found in inhibitor-treated cells the co-localization of the two proteins actually increased compared to wild-type cells. Lastly, a 30-fold increase in the ability to make lasting cell contacts was found in wild-type, untreated cells compared to inhibitor treated cells. Altogether these data demonstrate that de novo protein synthesis is needed in order for cells to continue to properly grow and spread, for proteins to be synthesized and co-localize properly at cell-cell contacts, and for cells to make lasting, non-random, cell contacts.
Subject (authority = RUETD)
Topic
Biology
Subject (authority = ETD-LCSH)
Topic
Cells--Growth--Regulation
Subject (authority = ETD-LCSH)
Topic
Cell interaction
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4781
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vi, 38 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Linda Sung
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000068787
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T37D2SRJ
Genre (authority = ExL-Esploro)
ETD graduate
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Sung
GivenName
Linda
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-04-30 17:25:31
AssociatedEntity
Name
Linda Sung
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
Back to the top
Version 8.5.3
Rutgers University Libraries - Copyright ©2024